The introduction of Darolutamide (ODM-201)
Darolutamide (ODM-201) is a structurally distinct non-steroidal androgen receptor (AR) antagonist being developed by Orion and Bayer as a treatment for prostate cancer.
Jan 17，2024 API
An orally PI3K inhibitor: Alpelisib
Alpelisib -an orally available phosphatidylinositol 3-kinase (PI3K) inhibitor with specific activity against PI3K alpha (PI3Kα)-is being developed by Novartis for the treatment of breast cancer.
Jan 17，2024 API
Safety and Efficacy of Chloral Hydrate in Outpatient Pediatrics for Sedation
Chloral hydrate is a clinical sedative drug used for the short-term treatment of insomnia and to relieve anxiety and induce sleep prior to surgery.
Jan 17，2024 Drugs
Is 1,3-Propane sultone carcinogenic to humans?
1,3-Propane sultone (1,3-PS) is a directly alkylating, genotoxic and carcinogenic substance.
Jan 17，2024 API
Streptomycin Sulfate: Biological Activities, Efficacy in Humans and Safety
Streptomycin sulfate is an aminoglycoside antibiotic used to treat Gram-negative infections, including tuberculosis. It has potential safety concerns and is no longer a first-line option.
Jan 17，2024 API
Anastrozole: Pharmacological Properties, Therapeutic Efficacy and Tolerability
Anastrozole is a potent aromatase inhibitor with superior efficacy and favorable tolerability over tamoxifen in the treatment of early-stage breast cancer.
Jan 17，2024 API
Belumosudil: Synthesis and Description
Belumosudil is an orally active Rho-associated coiled-coil-containing protein kinase-2 (ROCK2) inhibitor recently approved for chronic graft-versus-host disease (cGVHD) after failure of two prior line
Jan 17，2024 Inhibitors
Q：What is the connection between TBTU and HBTU?
A：HBTU is a standard coupling agent commonly used for the activation of free carboxylic acids during the solution and solid phase peptide synthesis.
Jan 17，2024 Biochemical Engineering
Ponesimod: Synthesis and Description
Ponesimod was approved in 2021 for the treatment of relapsing forms of multiple sclerosis (MS). This medication is an orally administered, selective sphingosine-
Jan 17，2024 Drugs
How is Difamilast synthesised?
Difamilast is synthesised in two steps by chemical reaction using the monobenzylated protocatechuic acid ethyl ester as a raw material.
Jan 17，2024 Inhibitors