Side-effects of Ethambutol
Ethambutol was discovered at Lederle Laboratories in 1961, when randomly selected synthetic compounds were being tested for antituberculosis activity. Chemically, it is dextro-2, 2u-(ethylenediimino)-
Mar 25，2022 API
Mechanism of action of Isoniazid
Isoniazid, isonicotinic acid hydrazide (INAH or INH), was discovered independently in 1952 at both Squibb and Roche Laboratories. Animal studies showed that isoniazid was a very potent antituberculosi
Mar 25，2022 API
Use and Safety of Grepafloxacin
Grepafloxacin (OPC-17116) is a broad-spectrum fluoroquinolone with the chemical structure (+)-1-cyclopropyl-6-fluoro-1,4-dihydro-5- methyl-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolone carboxylic acid
Mar 25，2022 API
Uses of Temafloxacin
Temafloxacin (6-fluoro-7-piperazino-4-quinolone)was discontinued in June 1992, only five months after gaining marketing approval. This was due to a high rate of reported adverse reactions, including s
Mar 25，2022 API
Uses of Fleroxacin
Fleroxacin (Ro 23-6240, AM 833) is different from fluoroquinolones such as ciprofloxacin or ofloxacin, since it is a trifluorinated quinolone, having three fluorine atoms rather than one attached to t
Mar 25，2022 API
Side effects of Tosufloxacin
Tosufloxacin was developed by Taisho-Toyama Chemistry (Ozexs) and became commercially available in 1990. It is a newer-generation oral fluoroquinolone with a broad spectrum of activity against Gramneg
Mar 25，2022 API
Imipenem: Antimicrobial Activity, Susceptibility, Administration and Dosage, Toxicity, Clinical Uses etc.
In the 1970s, Beecham Research Laboratories identified a carbapenem group, called olivanic acids, which were beta-lactamase inhibitors and broad-spectrum antibiotics (Butterworth et al., 1979).
Mar 25，2022 API
Side effects and Uses of Rufloxacin
Rufloxacin (MF 934), or 9-fluoro-10-(-methyl) piperazinyl-7-oxo-2,3- dihydro-7H-pyrido-(1,2,3, de) (1,4) benzothiazine-6-carboxylic acid, is an older-generation fluoroquinolone developed in 1989 with
Mar 25，2022 API
Side effects of Lomefloxacin
Lomefloxacin (Maxaquins, Pfizer) is an older-generation difluoroquinolone that has the chemical formula 1-ethyl-6,8-difluoro-1,4- dihydro-7-(3-methyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid. C
Mar 25，2022 API
Side effects of Sparfloxacin
Sparfloxacin (AT-4140, CI-978, PD 131501) is a newer-generation aminodifluoroquinolone with broad spectrum antibacterial activity. It has the chemical formula 5-amino-1-cyclopropyl-7-(cis-3,5-dimethyl
Mar 25，2022 API