| Identification | More | [Name]
3-Cyanopyridine | [CAS]
100-54-9 | [Synonyms]
3-CYANOPYRIDINE
3-PYRIDINECARBONITRILE
AKOS BBS-00004487
BETA-CYANOPYRIDINE
IFLAB-BB F2108-0102
NICOTINE ACID NITRILE
NICOTINIC ACID NITRILE
NICOTINONITRILE
SPECS AC-907/25014098
TIMTEC-BB SBB007554
3-Azabenzonitrile
3-Cyjanopirydyna
3-pyridinecarboxylicacid,nitrile
3-Pyridinenitrile
3-Pyridyl cyanide
3-Pyridylcarbonitrile
b-Cyanopyridine
Nitryl kwasu nikotynowego
nitrylkwasunikotynowego
Pyridine-3-carbonitrile | [EINECS(EC#)]
202-863-0 | [Molecular Formula]
C6H4N2 | [MDL Number]
MFCD00006372 | [Molecular Weight]
104.11 | [MOL File]
100-54-9.mol |
| Chemical Properties | Back Directory | [Appearance]
The cyanopyridines are as follows: 2-cyano-:
A white to tan liquid or solid. Almond odor. Boiling
point=2213℃
; freezing/melting point=27℃
; flash
point=89℃
. 3-cyano-: a colorless liquid or gray crystal-
line solid. | [Melting point ]
48-52 °C(lit.)
| [Boiling point ]
201 °C(lit.)
| [density ]
1.159
| [refractive index ]
1.5242 (estimate) | [Fp ]
184 °F
| [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
140g/l | [form ]
Crystalline Mass, Crystals or Chunks | [pka]
pK1:1.45(+1) (25°C) | [color ]
Colorless or white to yellow | [Stability:]
Incompatible with strong oxidizing agents, strong reducing agents, strong acids, strong bases. | [Water Solubility ]
140 g/L (20 ºC) | [Detection Methods]
HPLC | [BRN ]
107711 | [InChIKey]
GZPHSAQLYPIAIN-UHFFFAOYSA-N | [CAS DataBase Reference]
100-54-9(CAS DataBase Reference) | [NIST Chemistry Reference]
3-Pyridinecarbonitrile(100-54-9) | [EPA Substance Registry System]
100-54-9(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3
| [RTECS ]
QT3030000
| [TSCA ]
Yes | [HS Code ]
29333999 | [Hazardous Substances Data]
100-54-9(Hazardous Substances Data) |
| Hazard Information | Back Directory | [Potential Exposure]
Limits in Air
NIOSH IDLH525 mg/m3
NIOSH REL: (nitriles) 2 ppm, Ceiling Concentration, not
to be exceeded in any 15-minute work period. | [First aid]
If this chemical gets into the eyes, remove any
contact lenses at once and irrigate immediately for at least
15 minutes, occasionally lifting upper and lower lids. Seek
Medical attention immediately. If this chemical contacts the
skin, remove contaminated clothing and wash immediately
with soap and water. Seek medical attention immediately. If
this chemical has been inhaled, remove from exposure, begin
rescue breathing (using universal precautions, including
resuscitation mask) if breathing has stopped and CPR if
heart action has stopped. Transfer promptly to a medical
facility. When this chemical has been swallowed, get medi-
cal attention. Give large quantities of water and induce
vomiting. Do not make an unconscious person vomit. | [Shipping]
UN3276 Nitriles, liquid, toxic, n.o.s., Hazard
Class: 6.1; Labels: 6.1-Poisonous materials, Technical
Name Required, Potential Inhalation Hazard (Special
Provision 5). | [Incompatibilities]
Oxidizing agents, such as perchlorates,
peroxides, and permanganates. Nitriles may polymerize in
the presence of metals and some metal compounds. They
are incompatible with acids; mixing nitriles with strong
oxidizing acids can lead to extremely violent reactions.
Nitriles are generally incompatible with other oxidizing
agents such as peroxides and epoxides. The combination of
bases and nitriles can produce hydrogen cyanide. Nitriles
are hydrolyzed in both aqueous acid and base to give car-
boxylic acids (or salts of carboxylic acids). These reactions
generate heat. Peroxides convert nitriles to amides. Nitriles
can react vigorously with reducing agents. Acetonitrile and
propionitrile are soluble in water, but nitriles higher than
propionitrile have low aqueous solubility. They are also
insoluble in aqueous acids
. | [Chemical Properties]
The cyanopyridines are as follows: 2-cyano-:
A white to tan liquid or solid. Almond odor. Boiling
point=2213℃
; freezing/melting point=27℃
; flash
point=89℃
. 3-cyano-: a colorless liquid or gray crystal-
line solid. | [Chemical Properties]
white to beige solid | [Uses]
3-Cyanopyridine is used in the preparation of arylthiazolines and arylimidazolines via dibromodimethylhydantoin-catalyzed condensation of aryl nitriles with ethylene diamine or aminoethanethiol. | [Definition]
ChEBI: A nitrile that is pyridine substituted by a cyano group at position 3. | [Synthesis Reference(s)]
Tetrahedron Letters, 29, p. 2155, 1988 DOI: 10.1016/S0040-4039(00)86697-6 | [Purification Methods]
It is recrystallised to constant melting point from o-xylene/hexane. [Beilstein 22/2 V 115.] |
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