| Identification | Back Directory | [Name]
(R)-N-(2-(3-((3-hydroxypyrrolidin-1-yl)Methyl)iMidazo[2,1-b]thiazol-6-yl)phenyl)-2-naphthaMide | [CAS]
1001908-89-9 | [Synonyms]
SRT2183
(R)-N-(2-(3-((3-hydroxypyrrolidin-1-yl)Methyl)iMidazo[2,1-b]thiazol-6-yl)phenyl)-2-naphthaMide
2-Naphthalenecarboxamide, N-[2-[3-[[(3R)-3-hydroxy-1-pyrrolidinyl]methyl]imidazo[2,1-b]thiazol-6-yl]phenyl]- | [Molecular Formula]
C27H24N4O2S | [MDL Number]
MFCD22419825 | [MOL File]
1001908-89-9.mol | [Molecular Weight]
468.57 |
| Hazard Information | Back Directory | [Biological Activity]
SRT2183 is a small molecule activator of the sirtuin protein isoform SIRT1. | [in vitro]
1-20 μM SRT2183 can effectively inhibit cell growth and apoptosis. It can cause increased mRNA levels of genes involved in pro-apoptosis, growth arrest, and DNA damage response. SRT1720, SRT2183, SRT1460 and resveratrol have multiple off-target effects on some receptors, enzymes, transporters and ion channels. They are not direct activators of SIRT1. | [target]
| [storage]
Store at -20°C |
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