| Identification | More | [Name]
GADOLINIUM CHLORIDE | [CAS]
10138-52-0 | [Synonyms]
GADOLINIUM CHLORIDE
GADOLINIUM CHLORIDE, ANHYDRIDE
GADOLINIUM(III) CHLORIDE
Gadolinium chloride (GdCl3)
gadoliniumchloride(gdcl3)
gadoliniumtrichloride
GdCl3
GadoliniumchlorideanhydrideREOwhitepowder
Gadolinium (III) chloride, anhydrous
NMR STD/0.1MG/ML GDCL3/D2O4MM NANO TUBE
GADOLINIUM(III) CHLORIDE, ANHYDROUS, POW DER, 99.99%
GADOLINIUM(III) CHLORIDE ANHYDROUS 99.9%-GD)
Gadolinium(III) chloride, anhydrous, 99.9%
GADOLINIUM CHLORIDE, 99.9% ANHYDROUS
Gadolinium(III)chloride,anhydrous(99.9%-Gd)(REO)
GADOLINIUM(III) CHLORIDE, ANHYDROUS: 99.9% (REO)
Gadolinium Chloride, Anhydrous
Gadolinium(III) chloride, ultra dry, 99.99% (REO)
Gadolinium(III) chloride solution
Trichlorogadolinium | [EINECS(EC#)]
233-386-6 | [Molecular Formula]
Cl3Gd | [MDL Number]
MFCD00011024 | [Molecular Weight]
263.61 | [MOL File]
10138-52-0.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R38:Irritating to the skin. | [Safety Statements ]
S36/37:Wear suitable protective clothing and gloves . | [WGK Germany ]
3
| [RTECS ]
ZC0230000
| [F ]
10-21 | [TSCA ]
Yes | [HS Code ]
28273985 |
| Questions And Answer | Back Directory | [Physical Properties]
White monoclinic crystal; hygroscopic; density 4.52 g/cm3; melts at 609°C; soluble in water.
| [Preparation]
GdCl3 is prepared by heating gadolinium(III) oxide with excess of ammonium chloride above 200°C:
Gd2O3 + 6NH4Cl→2GdCl3 + 6NH3 + 3H2O
|
| Hazard Information | Back Directory | [Chemical Properties]
Colorless crystals, soluble in water, purities up to 99.9%. | [Uses]
GadoliniuM chloride, anhydrous is a calcium-sensing receptor agonist and is known to work by inducing NLRP3 inflammasome activation in bone marrow-derived macrophages.
GdCl3 is used for preparing gadolinium metal.
| [Uses]
Gadolinium(III) Chloride is used as chelating agents, which is essential for biomedical applications. It is also employed in the synthesis and nuclear magnetic resonance (NMR) studies of paramagnetic GdPCTA-[12] and GdPCTA-[13] complexes. It plays an important role as contrast agent for magnetic resonance imaging and an macrophage inhibitor. | [Definition]
ChEBI: Gadolinium trichloride is a gadolinium coordination entity. It has a role as a TRP channel blocker. | [Biological Activity]
gadolinium chloride is a casr agonist. the casr can activate the nlrp3 inflammasome by increasing intracellular ca2+ and decreasing cellular cyclic amp. thus, casr agonists may serve as a useful tool for exploring nlrp3 inflammasome associated inflammatory diseases such as cryopyrin-associated periodic syndromes, gout and atherosclerosis. in addition, gadolinium chloride has been demonstrated to block trpml channel currents, as well as other transient receptor potential (trp) channels.1. lee gs, subramanian n, kim ai, et al. the calcium-sensing receptor regulates the nlrp3 inflammasome through ca2+ and camp. nature, 2012, 492(7427): 123-127.2. nagata k, zheng l, madathany t, et al. the varitint-waddler (va) deafness mutation in trpml3 generates constitutive, inward rectifying currents and causes cell degeneration. proceedings of the national academy of sciences of the united states of america, 2008, 105(1): 353-358.3. del favero g, florio c, codan b, et al. the stretch-activated channel blocker gd3+ reduces palytoxin toxicity in primary cultures of skeletal muscle cells. chemical research in toxicology, 2012, 25(9): 1912-1920. | [storage]
Desiccate at RT |
|
|