| Identification | More | [Name]
8-CYCLOPENTYL-1,3-DIPROPYLXANTHINE | [CAS]
102146-07-6 | [Synonyms]
DPCPX
1,3-Dpcpx
PD 116,948
8-CYCLOPENTYL-1
PD-116948(DPCPX)
DPCPX, PD 116,948
3-DIPROPYLXANTHINE
cyclopentyl-1,3-dipropylxanthine
8-CYCLOPENTYL-1,3-DIPROPYLXANTHINE
1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE
8-Cyclopentyl-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
1,3-Dipropyl-8-cyclopentyl-7H-purine-2,6(1H,3H)-dione
1,3-Dipropyl-8-cyclopentylxanthine, DPCPX, PD 116,948
8-CYCLOPENTYL-1,3-DIPROPYLXANTHINE SELEC TIVE A1 ADENOSIN
8-Cyclopentyl-3,7-dihydro-1,3-dipropyl-1H-purin-2,6-dione
8-Cyclopentyl-3,7-dihydro-1,3-dipropyl-1H-purine-2,6-dione
8-Cyclopentyl-3,9-dihydro-1,3-dipropyl-1H-purine-2,6-dione
1H-Purine-2,6-dione, 8-cyclopentyl-3,7-dihydro-1,3-dipropyl-
1H-Purine-2,6-dione, 8-cyclopentyl-3,9-dihydro-1,3-dipropyl-
8-cyclopentyl-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
8-CYCLOPENTYL-1,3-DIPROPYLXANTHINE(DPCPX,1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE) | [Molecular Formula]
C16H24N4O2 | [MDL Number]
MFCD00055117 | [Molecular Weight]
304.39 | [MOL File]
102146-07-6.mol |
| Chemical Properties | Back Directory | [Appearance]
White Solid | [Melting point ]
178°C | [Boiling point ]
535.1±42.0 °C(Predicted) | [density ]
1.195±0.06 g/cm3(Predicted) | [storage temp. ]
Store at RT | [solubility ]
DMSO: >10 mg/mL
| [form ]
solid
| [pka]
9.01±0.70(Predicted) | [color ]
white
| [Usage]
DPCPX is a potent and very selective A1-adenosine receptor antagonist, with a Ki of 0.46 nM for A1 receptors in rat whole-brain membranes. Its 740-fold A1-selectivity is the highest reported for an adenosine antagonist | [Stability:]
Store tightly sealed at RT; Solutions at 4 deg C for several days | [CAS DataBase Reference]
102146-07-6(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
|
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
8-Cyclopentyl-1,3-dipropylxanthine has been used as an adenosine receptor (A1AR) antagonist in macrophages and human umbilical vein endothelial cells (HUVECs). It has also been used as A1AR antagonist in MCF-7 breast cancer cell line to test its anti-cancer effect. | [Uses]
DPCPX is a potent and very selective A1-adenosine receptor antagonist, with a Ki of 0.46 nM for A1 receptors in rat whole-brain membranes. Its 740-fold A1-selectivity is the highest reported for an adenosine antagonist | [Definition]
ChEBI: An oxopurine that is 7H-xanthine substituted at positions 1 and 3 by propyl groups and at position 8 by a cyclohexyl group. | [Biological Activity]
Potent and selective A 1 adenosine receptor antagonist, both in vitro and in vivo . K i values are 3.9, 130, 50 and 4000 nM for human A 1 , A 2A , A 2B and A 3 receptors respectively. | [Biochem/physiol Actions]
8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) is a selective A1?adenosine receptor antagonist. DPCPX possesses anti-cancer functionality. It induces apoptosis in breast cancer cells and favors mRNA expression of caspases. | [storage]
Room temperature |
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