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ChemicalBook--->CAS DataBase List--->1035638-91-5

1035638-91-5

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1035638-91-5 Structure

1035638-91-5 Structure
IdentificationBack Directory
[Name]

PF-6274484
[CAS]

1035638-91-5
[Synonyms]

PF-6274484
PF-6274484 >=98% (HPLC)
N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-2-propenamide
2-Propenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-
[Molecular Formula]

C18H14ClFN4O2
[MDL Number]

MFCD30182370
[MOL File]

1035638-91-5.mol
[Molecular Weight]

372.78
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMF: 33 mg/ml; DMSO: 25 mg/ml
[form ]

A crystalline solid
[color ]

Light yellow to orange
Hazard InformationBack Directory
[Description]

PF-6274484 is an irreversible EGFR kinase inhibitor that covalently reacts with active-site cysteine residues in the ATP binding pocket. PF-6274484 inhibits autophosphorylation of both wild type and mutant EGFR in tumor cells with IC50 values of 5.8 nM and 6.6 nM, respectively.
[storage]

Store at -20°C
Spectrum DetailBack Directory
[Spectrum Detail]

PF-6274484(1035638-91-5)1HNMR
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