| Identification | Back Directory | [Name]
6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid | [CAS]
1467057-23-3 | [Synonyms]
CS-2760
EOS-61684
PF 6409577
PF-06409577
PF 06409577;PF06409577
PF-06409577 >=98% (HPLC)
PF-06409577;PF 06409577;PF06409577
6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid
1H-Indole-3-carboxylic acid, 6-chloro-5-[4-(1-hydroxycyclobutyl)phenyl]- | [Molecular Formula]
C19H16ClNO3 | [MDL Number]
MFCD29917835 | [MOL File]
1467057-23-3.mol | [Molecular Weight]
341.79 |
| Chemical Properties | Back Directory | [Boiling point ]
610.9±55.0 °C(Predicted) | [density ]
1.468±0.06 g/cm3(Predicted) | [storage temp. ]
room temp | [solubility ]
DMSO: soluble | [form ]
powder | [pka]
3.60±0.30(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Description]
PF-06409577 is an activator of AMP-activated protein kinase (AMPK) heterotrimers (Kd = 9 nM for α1β1γ1).1 In vitro, it selectively activates β1-containing AMPK isoforms (EC50s = 2.18-7.03 nM) over β2-containing isoforms (EC50s = ≥10 μM). PF-06409577 has an EC50 value of 7 nM in an activation/protection TR-FRET assay using α1β1γ1 AMPK. In vivo, PF-06409577 (≥10 mg/kg) increases phosphorylation of AMPK in rat kidney. It decreases urinary albumin levels in a ZSF1 obese rat model of diabetes, metabolic syndrome, and renal disease when administered at a dose of 100 mg/kg. | [Uses]
PF-06409577 has been used to determine its potential as a therapeutic agent for diabetic nephropathy. | [General Description]
PF-06409577 is a 6-chloro-indole derivative obtained from 5-bromo-6-chloro-indole. | [Biochem/physiol Actions]
PF-06409577 preserves retinal pigment epithelium cells from UV radiation by activating AMPK (AMP-activated protein kinase) signaling. This orally bioavailable and possesses pharmacokinetic properties. PF-06409577 blocks de novo lipid and cholesterol synthesis pathways that shows a decrease in hepatic lipids and mRNA expression of markers of hepatic fibrosis. | [storage]
Store at -20°C |
|
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
|