| Hazard Information | Back Directory | [Description]
Aminooxy-PEG2-azide contain an azide and an aminooxy group. The aminooxy group reacts with an aldehyde or ketone group to form a oxime linkage. The azide group enables Click Chemistry. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended. | [Biological Activity]
Aminooxy-PEG2-azide is a PROTAC linker belonging to the PEG class, which can be used to synthesize PROTAC molecules.It is also a non-cleavable ADC linker containing 2-unit PEG, which can be used to synthesize antibody drug conjugates (ADCs). | [in vitro]
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. | [target]
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