| Identification | Back Directory | [Name]
FIBROBLAST GROWTH FACTOR, BASIC, HUMAN | [CAS]
106096-93-9 | [Synonyms]
BFGF
DRK1
KCNB1
kcb-1
HBFGF
FGF-2
RHBFGF
RHFGFB
NBBFGF
fce26184
BASIC FGF
FGC-BASIC
FGF-BASIC
BFGE HUMAN
FGF-B HUMAN
BFGF BOVINE
BFGF, HUMAN
FGF-2, HUMAN
FGF-2, BOVINE
Fgf-2 from rat
FGC-BASIC HUMAN
HUMAN FGF-BASIC
BOVINE FGF BASIC
BASIC FGF, HUMAN
FGF-BASIC (HUMAN)
FGF-BASIC PEPTIDE
FGF-2, Basic, Bovine
FGF-2, Basic, Human,
HUMAN OLIGOPEPTIDE-3
REC FGF BASIC (HUMAN)
Potassium channel Kv2.1
Fibroblast growth factlr
FGF-2, HUMAN, RECOMBINANT
basicastrolialgrowthfactor
basicfibroblastgrowthfactor
RECOMBINANT HUMAN FGF-BASIC
heparin-bindinggrowthfactor2
HEPARIN BINDING GROWTH FACTOR
FIBROBLAST GROWTH FACTOR, BASIC
FGF-2, Basic, Human, Recombinant,
BASIC FIBROBLAST GROWTH FACTOR,b-FGF
HUMAN FIBROBLAST GROWTH FACTOR-BASIC
BOVINE FIBROBLAST GROWTH FACTOR BASIC
BASIC FIBROBLAST GROWTH FACTOR, HUMAN
Anti-KV2.1 antibody produced in rabbit
FIBROBLAST GROWTH FACTOR, BASIC, HUMAN
FIBROBLAST GROWTH FACTOR BASIC PEPTIDE
FIBROBLAST GROWTH FACTOR, BASIC, BOVINE
FGF-2, Basic, Human, Recombinant, E. coli
ANTI-FGF2-T254 antibody produced in rabbit
FGF2, Basic Fibroblast Growth Factor ,bFGF
REC FIBROBLAST GROWTH FACTOR BASIC (HUMAN)
FIBROBLAST GROWTH FACTOR, BASIC, HUMAN，FGF2
BASIC FIBROBLAST GROWTH FACTOR (FGF 2) HUMAN
FIBROBLAST GROWTH FACTOR, BASIC, RECOMBINANT
Fibroblast Growth Factor, Basic, Human, Recomb.
Fibroblast Growth Factor-Basic human,FGF2, bFGF
recombinanthumanbasicfibroblastgrowthfactor,kcb-1
FIBROBLAST GROWTH FACTOR-BASIC, HEPARIN STABILIZED
basicfibroblastgrowthfactor,recombinanthuman,kcb-1
fibroblastgrowthfactor,basic,recombinanthuman,kcb-1
FIBROBLAST GROWTH FACTOR, BASIC, HUMAN, RECOMBINANT
FIBROBLAST GROWTH FACTOR, BASIC FROM*BOV INE PITUITA
fibroblast growth factor-basic from bovine pituitary
Potassium voltage-gated channel subfamily B member 1
fibroblast growth factor-basic heparin stabilized human
Recombinant Human Fibroblast Growth Factor-basic, rh-bFGF
Fibroblast Growth Factor (basic), Human, recombinant, Animal-derived-free | [Molecular Formula]
NULL | [MDL Number]
MFCD00081382 |
| Hazard Information | Back Directory | [Uses]
Fibroblast growth factor-basic (FGF-Basic) is required for the maintenance of human embryonic stem cells in culture, and various other stem cell lines, such as mesenchymal stem (stroma) cells (MSC). | [General Description]
Fibroblast growth factor-basic (FGF-Basic) is found in basement membranes and sub-endothelial extracellular matrix. FGF-Basic is induced early in the development of the embryo where it is necessary (but not sufficient) for pluripotency and self-renewal of embryonic stem cells (ESC) and lineage defined stem cells; wherein it functions to support proliferation and inhibit differentiation. Self-renewal of hESC depends upon activation of the Activin/Nodal/Smad2,3 branch and suppression of the BMP/GDF/Smad5 branch of the TGFβ-family cell signaling program. FGF-Basic is a competence factor for Nodal support of pluripotency. Activin-A is necessary and sufficient to maintain stemness. It induces the expression of both Nodal and FGF-Basic in human ES cells. | [Biochem/physiol Actions]
FGF2 (fibroblast growth factor 2, also referred to as BFGF (basic fibroblast growth factor)) interacts with FGFR1 (fibroblast growth factor receptor 1), FGFR2 and FGFR3. It stimulates the proliferation of a wide variety of cells including mesenchymal, neuroectodermal and endothelial cells. FGF2 also determines the fate of neural precursor cells and promotes neuronal axon regeneration. It plays an important role in spinal cord injury repair. FGF2 is known to stimulate angiogenesis and is associated with cancer development. High levels of FGF2 are present in the kidney of children with HIV (human immunodeficiency virus)-renal diseases. The FGF2 mRNA is a target of miRNA miR-503. |
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