| Identification | More | [Name]
METHYL ISOCYANOACETATE | [CAS]
39687-95-1 | [Synonyms]
ISOCYANOACETIC ACID METHYL ESTER
METHYL ISOCYANOACETATE
METHYL ISOCYANOACETATE, TECH., 95%
Methyl isocyanoformate
Methyl isocyanoacetate, technical grade
Methyl isocyanoacetate, 95%, tech.
(2-Oxo-2-methoxyethyl) isocyanide
2-Isocyanoacetic acid methyl ester
2-Oxo-2-methoxyethyl isocyanide
Methyl 2-isocyanoacetate | [EINECS(EC#)]
254-593-8 | [Molecular Formula]
C4H5NO2 | [MDL Number]
MFCD00000006 | [Molecular Weight]
99.09 | [MOL File]
39687-95-1.mol |
| Chemical Properties | Back Directory | [Appearance]
CLEAR YELLOW TO BROWN LIQUID | [Boiling point ]
75-76 °C10 mm Hg(lit.) | [density ]
1.09 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.417(lit.)
| [Fp ]
193 °F
| [storage temp. ]
−20°C
| [form ]
Liquid | [color ]
Clear yellow to brown | [Water Solubility ]
Miscible with organic solvents. Slightly miscible with water. | [BRN ]
3537963 | [CAS DataBase Reference]
39687-95-1(CAS DataBase Reference) | [Storage Precautions]
Light sensitive;Moisture sensitive |
| Safety Data | Back Directory | [Hazard Codes ]
C | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 2922 8/PG 2
| [WGK Germany ]
3
| [F ]
8-9-32-13-19 | [HazardClass ]
8 | [PackingGroup ]
II | [HS Code ]
29291090 |
| Hazard Information | Back Directory | [Chemical Properties]
CLEAR YELLOW TO BROWN LIQUID | [Uses]
Methyl isocyanoacetate has been used in the copper-catalyzed, diastereoselective synthesis of oxazolines. | [Uses]
Methyl isocyanoacetate is used in the copper-catalyzed, diastereoselective synthesis of oxazolines. It is involved in the direct aldol reaction with carbonyl compounds to prepare corresponding oxazoline by using catechol-copper network catalyst. Further, it is also involved in four-component Ugi condensation reaction. It undergoes asymmetric aldol reaction with fluorinated benzaldehyde using gold(I) as a catalyst. | [General Description]
Methyl isocyanoacetate undergoes direct aldol reaction with carbonyl compounds in the presence of solid-phase catechol-copper network catalyst to yield corresponding oxazolines. It also participates in four-component Ugi condensation reaction. |
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