| Identification | More | [Name]
TEPP | [CAS]
107-49-3 | [Synonyms]
ETHYL PYROPHOSPHATE
HETP
KILLAZ
MORTOPAL(R)
NIFOS T(R)
O,O-TEPP
TEPP
TETRAETHYL DIPHOSPHATE
TETRAETHYLPYROPHOSPHATE
TETRON
VAPOTONE(R)
bis-o,o-diethylphosphoricanhydride
diphosphoricacid,tetraethylester
diphosphoricacidtetraethylester
ea1285
ent18,771
ethylpyrophosphate(et4p2o7)
fosvex
grisol
hept | [EINECS(EC#)]
203-495-3 | [Molecular Formula]
C8H20O7P2 | [MDL Number]
MFCD00055459 | [Molecular Weight]
290.19 | [MOL File]
107-49-3.mol |
| Chemical Properties | Back Directory | [Appearance]
Water-white to amber liquid depending
on purity; hygroscopic. Miscible
with water and all organic solvents except aliphatic
hydrocarbons; hydrolyzed in water with formation
of mono-, di-, and triethyl orthophosphates; water
solutions attack metals; commer | [Melting point ]
208-213℃ (decomposition) | [Boiling point ]
200℃ (0.3 Torr) | [density ]
1.901 g/cm3 (25 ºC) | [vapor pressure ]
4.7 at 30 °C (Windholz et al., 1983)1.55 at 20 °C (quoted, Verschueren, 1983) | [refractive index ]
1.4270 (20℃) | [Fp ]
>100 °C | [storage temp. ]
2-8°C | [solubility ]
Miscible with acetone, benzene, carbon tetrachloride, chloroform, ethanol, ethylene glycol,
glycerol, methanol, propylene glycol, toluene, xylene (Windholz et al., 1983), and ethylbenzene. | [form ]
solid | [Water Solubility ]
Miscible | [Merck ]
13,9279 | [Exposure limits]
NIOSH REL: TWA 0.05 mg/m3, IDLH 5 mg/m3; OSHA PEL: 0.05
mg/m3; ACGIH TLV: TWA 0.004 ppm. | [CAS DataBase Reference]
107-49-3(CAS DataBase Reference) | [EPA Substance Registry System]
Tetraethyl pyrophosphate (107-49-3) |
| Safety Data | Back Directory | [Hazard Codes ]
T+,N | [Risk Statements ]
R27/28:Very Toxic in contact with skin and if swallowed .
R50:Very Toxic to aquatic organisms. | [Safety Statements ]
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S38:In case of insufficient ventilation, wear suitable respiratory equipment .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S61:Avoid release to the environment. Refer to special instructions safety data sheet . | [RIDADR ]
3018 | [RTECS ]
UX6825000 | [HazardClass ]
6.1(a) | [PackingGroup ]
I | [HS Code ]
29199000 | [Safety Profile]
Human poison by ingestion and intramuscular routes. Experimental poison by ingestion, skin contact, intraperitoneal, intramuscular, subcutaneous, parenteral, and intravenous routes. Human systemic effects by ingestion, intramuscular, and parenteral routes: paresthesia, wakefulness, excitement, muscle contraction or spasticity, nausea or vomiting and other gastrointestinal changes. The action is sidar to that of parathion: causing an irreversible inhbition of the cholinesterase molecules and the consequent accumulation of large amounts of acetylcholine. Small doses at frequent intervals are largely additive. When heated to decomposition it emits toxic fumes of POx. See also PARATHION. | [Hazardous Substances Data]
107-49-3(Hazardous Substances Data) | [Toxicity]
LD50 orally in male rats: 1.1 mg/kg (Gaines) | [IDLA]
5 mg/m3 |
| Hazard Information | Back Directory | [General Description]
Water-white to amber liquid, depending on purity. | [Reactivity Profile]
Organophosphates, such as TETRAETHYL PYROPHOSPHATE, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides. | [Air & Water Reactions]
Hygroscopic. Hydrolyzed in water with formation of mono. di, and triethyl orthophosphates, water solutions attack metal surfaces. Reacts slowly with water to form phosphoric acid | [Health Hazard]
Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. | [Potential Exposure]
A potential danger to those engaged in the manufacture, formulation and application of this aphicide and acaricide; used as an insecticide to control aphids, thrips, and mites; as an anticholinesterase. | [Fire Hazard]
Combustible material: may burn but does not ignite readily. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form. | [First aid]
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Speed in removing material from skin is of extreme importance. Shampoo hair promptly if contaminated. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give a slurry of activated charcoal in water to drink. Do NOT induce vomiting. | [Shipping]
UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN3018 Organophosphorus pesticides, liquid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. Note: See T:0305 for TEPP 1compressd gas. | [Incompatibilities]
Tetraethyl pyrophosphate may be susceptible to formation of highly toxic and flammable phosphine gas in the presence of hydrides and other strong reducing agents. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides. Hygroscopic. Hydrolyzed in water with formation of mono. di-, and triethyl-orthophosphates. Reacts slowly with cold water forming phosphoric acid. Attacks metals in the presence of water. | [Chemical Properties]
TEPP is a colorless to amber liquid. Some liquid formulation may contain flammable organic solvents. A solid (glass-like state) below 0C. May be transported in molten form. Faint, fruity, aromatic odor. | [Chemical Properties]
Tetraethyl pyrophosphate and compressed gas mixture is a liquid charged with a gas. It is a colorless liquid. Its vapor is heavier than air. Faint, fruity, aromatic odor. | [Chemical Properties]
Water-white to amber liquid depending
on purity; hygroscopic. Miscible
with water and all organic solvents except aliphatic
hydrocarbons; hydrolyzed in water with formation
of mono-, di-, and triethyl orthophosphates; water
solutions attack metals; commercial material contains
40% TEPP. | [Waste Disposal]
Return refillable compressed gas cylinders to supplier. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. TEPP is 50% hydrolyzed in water in 6.8 hours @ 25℃, and 3.3 hours @ 38℃; 99% hydrolysis requires 45.2 hours @ 25 ℃, or 21.9 hours @ 38℃. Hydrolysis of TEPP yields nontoxic products. Incineration is, however, an option for TEPP disposal. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office. | [Physical properties]
Colorless to amber liquid with an agreeable, fruity odor | [Uses]
Insecticide for aphids and mites, rodenticide. | [Uses]
Insecticide for mites and aphids; rodenticide. | [Definition]
ChEBI: TEPP is an organic diphosphate. | [Synthesis Reference(s)]
The Journal of Organic Chemistry, 15, p. 637, 1950 DOI: 10.1021/jo01149a031 | [Hazard]
Toxic by skin contact, inhalation, or
ingestion; rapidly absorbed through skin; repeated
exposure may, without symptoms, be increasingly
hazardous; cholinesterase inhibitor, use may be
restricted. | [Environmental Fate]
Chemical/Physical. Tetraethyl pyrophosphate is quickly hydrolyzed by water. The
hydrolysis half-lives at 25 and 38°C are 6.8 and 3.3 hours, respectively (Sittig, 1985).
Decomposes at 170–213°C releasing large amounts of ethylene (Hartley and Kidd,
1987; Keith and Walters, 1992). |
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