| Identification | Back Directory | [Name]
INSULIN | [CAS]
11070-73-8 | [Synonyms]
INSULIN
ProMaxx
27USP U/MG
insulin(ox)
Insulin beef
bovineinsulin
INSULIN BOVINE
Insulin (cattle)
Insulinfrombovine
insulin bovine usp
INSULIN (powder)
Insulin, Crystalline
INSULIN, BOVINE, SODIUM
recombinant humaninsulin
(100 mg) Insulin (Beef)
huMan insulin,recoMbinant
HuMan recoMbinant Insulin
Insulin froM bovine pancr
INSULIN, MASS SPEC STANDARD
Insulin from bovine pancreas
INSULIN (BOVINE PANCREAS) >
ProteoMass? Insulin MALDI-MS Standard
proteomasstm insulin maldi-ms standard
insulin hybri-max from bovine pancreas
INSULIN, BOVINE SOLUTION CELL CULTURE*TE
Insulin Solution, Human recombinant (10mg/ml)
Insulin (Beef) (100 mg) (COLD SHIPMENT REQUIRED)
INSULIN FROM BOVINE PANCREAS*CELL CULTUR E TESTED
INSULIN HUMAN, RECOMBINANT EXPRESSED IN E. COLI SOD
INSULIN FROM BOVINE PANCREAS GAMMA-*IRRA DIATED CELL | [EINECS(EC#)]
234-291-2 | [Molecular Formula]
C254H377N65O75S6 | [MDL Number]
MFCD02321930 | [Molecular Weight]
5733.49 |
| Chemical Properties | Back Directory | [Definition]
A polypeptide hormone having a molecular weight of 5733. It is formed in the islets of Langerhans located in the pancreas and was so named for this reason. Insulin is composed of 16 amino acids arranged in a coiled chain and crosslinked in several places | [Appearance]
white solid | [storage temp. ]
2-8°C
| [solubility ]
acidified water, pH 2.0: 2 mg/mL
| [form ]
solution
| [color ]
White to off-white | [Stability:]
Stable. Incompatible with strong oxidizing agents. Keep refrigerated at-20 C | [Merck ]
13,5003 | [CAS DataBase Reference]
11070-73-8 |
| Hazard Information | Back Directory | [Chemical Properties]
white solid | [Hazard]
Overdosage can be fatal. | [Uses]
Antidiabetic. | [Uses]
Insulin is a peptide hormone regulating the metabolism of carbohydrates and fats. It is used in the treatment of those suffering from the diabetes type I and II metabolic disorders. Regulates the absorption of glucose from the blood to skeletal muscles and fat storage. | [Indications]
More than a century has passed since von Mering and
Minkowski first demonstrated that pancreatectomized
dogs exhibited signs and symptoms characteristic of diabetes
mellitus. Shortly thereafter, Banting and Best used
pancreatic extracts to reverse these symptoms in diabetic
patients, thus providing a basis for establishing a
cause-and-effect relationship between insulin deficiency
and diabetes. Insulin was subsequently isolated, crystallized,
and eventually synthesized in the laboratory.
Insulin replacement therapy has been widely used in the
clinical management of diabetes mellitus for more than
70 years. In 1982, recombinant DNA (rDNA) derived
human insulin was first produced and is now widely used
instead of insulin derived from beef or pork. More recently,
insulin analogues have been produced that modulate
the activity and rate of insulin action. | [Biochem/physiol Actions]
Two-chain polypeptide hormone produced by the β-cells of pancreatic islets. Its molecular weight is ~5800 Da. The α and β chains are joined by two interchain disulfide bonds. The α chain contains an intrachain disulfide bond. Insulin regulates the cellular uptake, utilization, and storage of glucose, amino acids, and fatty acids and inhibits the breakdown of glycogen, protein, and fat. | [Pharmacology]
Insulin is usually administered subcutaneously. Depending
on the type of insulin being administered,
the rate of insulin absorption can be modulated by altering the polymerization of the insulin molecule (e.g.,
monomers, dimers, or hexamers). Intramuscular injections
of insulin are used less often because absorption is
more rapid. Being a polypeptide hormone, insulin is
readily inactivated if administered orally. In emergencies,
such as severe diabetic ketoacidosis, insulin can be
given intravenously. Clinical studies are examining the
efficacy and safety of inhaled insulin, which may be
promising for some patients.
Once insulin enters the circulation, its plasma halflife
is less than 10 minutes. Hepatic insulinases destroy
approximately 50% of circulating insulin, with the remainder
degraded by circulating proteases. Therefore,
only a relatively small amount of the total endogenous
insulin secreted ever reaches the peripheral tissues.
Although a number of tissues accumulate small amounts
of insulin, the liver and kidney are the principal sites of
hormone uptake and degradation. Insulin metabolism is
accomplished both through the actions of an insulinspecific
protease found in the cytosol of many tissues
and by the reductive cleavage of the insulin disulfide
bonds by glutathione–insulin transhydrogenase. In the
kidney, insulin that undergoes glomerular filtration is almost
completely reabsorbed and metabolized within the
proximal convoluted tubules of the nephron. | [Clinical Use]
According to the DCCT and the UK Prospective Diabetes study, insulin and/or insulin analogues are the standard treatment
for type 1, gestational, and some type 2 diabetes. | [Side effects]
Insulin Overdose and Diabetic Coma
The most common and serious reaction to insulin therapy is hypoglycemia. It is important that patients with diabetes,
especially those receiving insulin therapy, be able to recognize the signs and symptoms of hypoglycemia. Symptoms of
hypoglycemia may be evident with a plasma glucose level at 60 to 80 mg/dL. Severe hypoglycemia can lead to convulsions
and coma. Patients that vigorously attempt to achieve euglycemia to avoid various vascular complications risk increased
frequency of hypoglycemic episodes.
In the DCCT, the incidence of severe hypoglycemic reactions was threefold higher in the intensive insulin therapy group than in the conventional therapy group. | [Metabolism]
Insulin degradation occurs primarily in the liver and kidney. Of that which is secreted from the pancreatic islet cells, 50%
reaches the liver via the portal vein and undergoes disulfide bond cleavage catalyzed by glutathione insulin
transhydrogenase (insulinase). This is followed by proteolytic degradation before entry into the general circulation. Insulin
is filtered by the renal glomeruli and can then be reabsorbed or degraded by the tubules. At the tissue level, insulin
degradation occurs to a limited extent at the cell surface. | [storage]
Store at -20°C |
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