| Identification | Back Directory | [Name]
Mal-PEG5-CH2CH2Mal | [CAS]
113387-03-4 | [Synonyms]
Mal-PEG5-CH2CH2Mal
1H-Pyrrole-2,5-dione, 1,1'-(3,6,9,12,15-pentaoxaheptadecane-1,17-diyl)bis- | [Molecular Formula]
C20H28N2O9 | [MDL Number]
MFCD31706204 | [MOL File]
113387-03-4.mol | [Molecular Weight]
440.44 |
| Hazard Information | Back Directory | [Biological Activity]
Mal-PEG5-mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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