| Identification | Back Directory | [Name]
Mal-PEG4-Val-Cit-PAB-PNP | [CAS]
2112738-09-5 | [Synonyms]
Mal-PEG4-Val-Cit-PAB-PNP
L-Ornithinamide, N-[15-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxo-4,7,10,13-tetraoxapentadec-1-yl]-L-valyl-N5-(aminocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]- | [Molecular Formula]
C40H53N7O15 | [MDL Number]
MFCD30828694 | [MOL File]
2112738-09-5.mol | [Molecular Weight]
871.89 |
| Hazard Information | Back Directory | [Description]
Mal-PEG4-Val-Cit-PAB-PNP is a cleavable ADC linker. The Val-Cit linkers can be cleaved by Cathepsin B. Maleimide (Mal) group is reactive toward thiol groups. PEG space improve compound's aqueous solubility. PNP is a good leaving group. | [Biological Activity]
Mal-PEG4-Val-Cit-PAB-PNP is a cleavable ADC linker containing 4 units of PEG, which can be used to synthesize antibody drug conjugates (ADC). | [in vitro]
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. | [target]
|
|
| Company Name: |
Abydos Scientific
|
| Tel: |
025-84767922 18936879710 |
| Website: |
http://www.abydoscientific.com/index.html |
|