| Identification | Back Directory | [Name]
CLP257 | [CAS]
1181081-71-9 | [Synonyms]
CLP257
(5Z)-5-[(4-Fluoro-2-hydroxyphenyl)methylene]-2-(tetrahydro-1-(2H)-pyridazinyl)-4(5H)-thiazolone
4(5H)-Thiazolone, 5-[(4-fluoro-2-hydroxyphenyl)methylene]-2-(tetrahydro-1(2H)-pyridazinyl)-, (5Z)- | [Molecular Formula]
C14H14FN3O2S | [MDL Number]
MFCD28166488 | [MOL File]
1181081-71-9.mol | [Molecular Weight]
307.34 |
| Chemical Properties | Back Directory | [Boiling point ]
473.3±55.0 °C(Predicted) | [density ]
1.50±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 20 mg/ml | [form ]
powder | [pka]
7.23±0.40(Predicted) | [color ]
white to yellow to light brown |
| Hazard Information | Back Directory | [Uses]
CLP257 has been used as a K+- Cl- cotransporter 2 (KCC2) enhancer in human neuron culture. | [Biochem/physiol Actions]
CLP257 is a selective K+-Cl? cotransporter KCC2 activator that restored impaired Cl? transport in neurons with reduced KCC2 activity. Apparently, CLP257 modulates plasmalemmal KCC2 protein turnover post-translationally. | [storage]
Store at +4°C |
|
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
DC Chemicals
|
| Tel: |
021-58447131 13564518121 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList927327/0.htm |
| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 13348960310 |
| Website: |
http://www.weikeqi-biotech.com/ |
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
|