| Identification | Back Directory | [Name]
MK-2 Inhibitor III | [CAS]
1186648-22-5 | [Synonyms]
MK2-IN-3 hydrate
MK-2 Inhibitor III
MK-2 INHIBITOR III (COMPOUND 16)
MK-2 Inhibitor III - CAS 1186648-22-5 - Calbiochem
2-(2-quinolin-3-ylpyridin-4-yl)-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one:hydrate | [Molecular Formula]
C21H18N4O2 | [MOL File]
1186648-22-5.mol | [Molecular Weight]
358.4 |
| Chemical Properties | Back Directory | [Melting point ]
>255°C (dec.) | [storage temp. ]
+2C to +8C | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Pale yellow solid | [color ]
Off-White to Pale Yellow |
| Hazard Information | Back Directory | [Description]
MAP kinase-activated protein kinase 2 (MAPKAP2, MK2) is a stress-activated serine/threonine protein kinase that is phosphorylated by p38 MAP kinase and is involved in diverse cellular functions with a central role in inflammation. MK2 inhibitor III is a potent, cell-permeable inhibitor of MK2 (IC50 = 8.5 nM). It less potently blocks MK3 and MK5 (IC50s = 210 and 81 nM, respectively) and is weak or inactive against several other kinases, including other p38 MAP kinase targets. MK2 inhibitor III prevents LPS-induced synthesis of TNF-α in human monocyte-like U937 cells (IC50 = 4.4 μM). | [Uses]
MAP kinase-activated protein kinase 2 (MAPKAP2, MK2) is a stress-activated serine/threonine protein kinase that is phosphorylated by p38 MAP kinase and is involved in diverse cellular functions with a central role in inflammation. MK2 inhibitor III is a potent, cell-permeable inhibitor of MK2 (IC50 = 8.5 nM). It less potently blocks MK3 and MK5 (IC50s = 210 and 81 nM, respectively) and is weak or inactive against several other kinases, including other p38 MAP kinase targets. MK2 inhibitor III prevents LPS-induced synthesis of TNF-α in human monocyte-like U937 cells (IC50 = 4.4 μM).[Cayman Chemical] | [storage]
Store at -20°C |
|
| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 13348960310 |
| Website: |
http://www.weikeqi-biotech.com/ |
|