| Identification | Back Directory | [Name]
Crisaborole intermediate | [CAS]
1187188-60-8 | [Synonyms]
Crisaborole Impurity 59
Crisaborole Impurity 37
Crisaborole Impurity 28
5-(4-(hydroxymethyl)phenoxy)benzo[c][1,2]oxaborol-1(3H)-ol
5-(4-(Hydroxylmethyl)phenoxy)benzo[c][1,2]oxaborol-1-(3H)-ol | [Molecular Formula]
C14H13BO4 | [MOL File]
1187188-60-8.mol | [Molecular Weight]
256.06 |
| Hazard Information | Back Directory | [Uses]
5-(4-(Hydroxyl Methyl)phenoxy)benzo[c][1,2]oxaborol-1-(3H)-ol is an impurity for Crisaborole(H947928). Crisaborole is a series of phenoxy benzoxaboroles were synthesized and screened for their inhibitory activity against PDE4 and cytokine release. 5-?(4-?Cyanophenoxy)?-?2,?3-?dihydro-?1-?hydroxy-?2,?1-?benzoxaborole (AN2728) showed potent activity both in vitro and in vivo. AN2728 is being studied as an anti-inflammatory agent. |
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