1187188-60-8
中文名称
克立硼罗中间体
英文名称
Crisaborole intermediate
CAS
1187188-60-8
分子式
C14H13BO4
分子量
256.06
MOL 文件
1187188-60-8.mol
更新日期
2024/11/21 14:22:40
1187188-60-8 结构式
基本信息
中文别名
克立硼罗杂质07克立硼罗杂质37
克立硼罗杂质59
5-(4-(羟甲基)苯氧基)苯并[C] [1,2]氧杂硼醇-1(3H)-醇
英文别名
Crisaborole Impurity 28Crisaborole Impurity 37
Crisaborole Impurity 59
5-(4-(hydroxymethyl)phenoxy)benzo[c][1,2]oxaborol-1(3H)-ol
5-(4-(Hydroxylmethyl)phenoxy)benzo[c][1,2]oxaborol-1-(3H)-ol
所属类别
分析化学：药典标准品和杂质标准品应用领域
用途一
5-(4-(Hydroxyl Methyl)phenoxy)benzo[c][1,2]oxaborol-1-(3H)-ol is an impurity for Crisaborole(H947928). Crisaborole is a series of phenoxy benzoxaboroles were synthesized and screened for their inhibitory activity against PDE4 and cytokine release. 5-?(4-?Cyanophenoxy)?-?2,?3-?dihydro-?1-?hydroxy-?2,?1-?benzoxaborole (AN2728) showed potent activity both in vitro and in vivo. AN2728 is being studied as an anti-inflammatory agent.