| Chemical Properties | Back Directory |
[Appearance]
Brown to rust Crystalline powder |
[Melting point ]
198-202 °C (dec.) (lit.) |
[Boiling point ]
322.46°C (rough estimate) |
[density ]
1.3617 (estimate) |
[refractive index ]
1.6890 (rough estimate) |
[solubility ]
DMSO (Slightly), Methanol (Slightly) |
[form ]
Crystalline Powder |
[pka]
8.08±0.19(Predicted) |
[color ]
Rust brown to brown |
[Water Solubility ]
insoluble |
[Detection Methods]
HPLC |
[BRN ]
972974 |
[CAS DataBase Reference]
121-88-0(CAS DataBase Reference) |
[IARC]
3 (Vol. 57) 1993 |
[EPA Substance Registry System]
121-88-0(EPA Substance) |
| Hazard Information | Back Directory |
[General Description]
Brown amorphous granules or powder. Melting point 198-202°C. |
[Reactivity Profile]
2-AMINO-5-NITROPHENOL(121-88-0) is a reducing agent. Incompatible with strong oxidizing agents. Reacts slowly with oxygen in the air at room temperature. Stable at temperatures up to 140°F for two weeks when kept in the dark and under nitrogen. Stable under nitrogen for up to 24 weeks 77°F. Incompatible with strong bases . Incompatible with acid chlorides and acid anhydrides. |
[Air & Water Reactions]
Is slowly oxidized by air at room temperature. Insoluble in water. |
[Fire Hazard]
Flash point data for this chemical are not available. 2-AMINO-5-NITROPHENOL is probably combustible. |
[Chemical Properties]
Brown to rust Crystalline powder |
[Uses]
2-Amino-5-nitrophenol has been used as starting material in the synthesis of series of (Z)-2-(substituted aryl)-N-(3-oxo-4-(substituted carbamothioyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl) hydrazine carboxamides, as semi permanent (nonoxidative) hair colorant and as toner in permanent (oxidative) hair dye products, in synthesis of series of 7-benzylamino-2H-1,4-benzoxazin-3(4H)-ones, anticonvulsant agents. Also used as a reactant for, diazotation and coupling reactions, preparation of biologically and pharmacologically active molecules. It is also applied in hair dyes and to make azo dyes. |
[Uses]
2-Amino-5-nitrophenol is used in hair dyes and as an intermediate
in preparing azo dyes. |
[Uses]
Reactant for:• ;Diazotation and coupling reactions1• ;Preparation of biologically and pharmacologically active molecules2 |
[Definition]
ChEBI: 2-Amino-5-nitrophenol is a member of 3-nitrophenols. |
[Carcinogenicity]
The potential carcinogenicity of 2-amino-5-nitrophenol
was tested by NTP by oral administration (gavage) in
corn oil to F344/N rats (100 and 200 mg/kg) and B6C3F1
mice (400 and 800 mg/kg) for 2 years. There was some
evidence of carcinogenic activity in low-dose male rats, as
indicated by increased incidence of acinar cell adenomas of
the pancreas. No evidence of carcinogenic activity was found
among female rats and the low-dose groups of male and
female mice. The poor survival rates in the high-dose male
rats and high-dose male and female mice reduced the sensitivity
for detecting potential carcinogenic response. |
[Purification Methods]
Crystallise the phenol from water. [Beilstein 13 IV 803.] |