| Identification | More | [Name]
1-Hydroxybenzotriazole hydrate | [CAS]
123333-53-9 | [Synonyms]
1,2,3-BENZOTRIAZOL-1-OL MONOHYDRATE
1H-1,2,3-BENZOTRIAZOL-1-OL HYDRATE
1H-BENZOTRIAZOLE, 1-HYDROXY-, HYDRATE
1-HYDROXYBENZOTRIAZOLE HYDRATE
1-HYDROXYBENZOTRIAZOLE MONOHYDRATE
1-HYDROXYBENZOTRIAZOLE N-HYDRATE
1-HYDROXYBENZOTRIAZOL MONOHYDRATE
HOBT
HOBT H2O
HOBT HYDRATE
HOBTM
HOBT MONOHYDRATE
N-HYDROXYBENZOTRIAZOLE H2O
N-HYDROXYBENZOTRIAZOLE HYDRATE
N-HYDROXYBENZOTRIAZOLE MONOHYDRATE
N-HYDROXYBENZOTRIAZOL MONOHYDRATE
TIMTEC-BB SBB000114
1H-1,2,3-benzotriazol-1-ol hydrate solution
1-HYDROXYBENZOTRIAZOLE 15 WT. % SOLUTI&
1-Hydroxybenzotriazole99%Puriss | [EINECS(EC#)]
219-989-7 | [Molecular Formula]
C6H7N3O2 | [MDL Number]
MFCD00065690 | [Molecular Weight]
153.14 | [MOL File]
123333-53-9.mol |
| Chemical Properties | Back Directory | [Appearance]
White to off-white powder | [Melting point ]
155-158 °C(lit.) | [Boiling point ]
248.8°C (rough estimate) | [density ]
1.065 g/cm | [refractive index ]
1.6910 (estimate) | [storage temp. ]
Store at RT. | [solubility ]
DMF: 100 mg/mL, clear
| [form ]
Solid | [color ]
White to Off-White | [Water Solubility ]
slightly soluble | [Usage]
A common additive for peptide coupling.
| [Detection Methods]
HPLC,NMR | [BRN ]
4515 | [Stability:]
Hygroscopic | [CAS DataBase Reference]
123333-53-9(CAS DataBase Reference) | [Storage Precautions]
Heat sensitive |
| Safety Data | Back Directory | [Hazard Codes ]
F | [Risk Statements ]
R5:Heating may cause an explosion.
R11:Highly Flammable. | [Safety Statements ]
S15:Keep away from heat .
S16:Keep away from sources of ignition-No smoking .
S35:This material and its container must be disposed of in a safe way .
S7/9:Keep container tightly closed and in a well-ventilated place .
S33:Take precautionary measures against static discharges . | [RIDADR ]
UN 3380 4.1/PG 1
| [WGK Germany ]
-
| [F ]
4.10-8 | [Hazard Note ]
Highly Flammable | [HS Code ]
29339900 |
| Hazard Information | Back Directory | [Chemical Properties]
White to off-white powder | [Uses]
1-Hydroxybenzotriazole hydrate can be used as a condensation reagent to prepare:
- Poly-γ-glutamic acid methyl ester from a dimer of γ-glutamic acid.
- Oxadiazoles via cyclo condensation of amidoximes with trifluoroacetic anhydride or benzoic acid derivatives.
| [Uses]
A common additive for peptide coupling.
| [Uses]
additive for oligonucleotide couplings and in racemization-free peptide couplings | [General Description]
1-Hydroxybenzotriazole is a coupling reagent used to synthesize amides by the condensation reaction between the activated ester/acid and the amino group of protected amino acids. It is also used as a racemization suppressor during peptide synthesis. | [reaction suitability]
reaction type: Addition Reactions | [Toxics Screening Level]
The ITSL 1-Hydroxy benzotriazole has been changed from 0.04 μg/m3 to 0.1 μg/m3
based on an annual averaging time. |
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