| Identification | More | [Name]
5-Chloro-8-hydroxyquinoline | [CAS]
130-16-5 | [Synonyms]
5-CHLORO-8-HYDROXYQUINOLINE
5-CHLORO-8-QUINOLINOL
5-CHLOROOXINE
5-CHLOROQUINOPHENOL
cloxiquine
DERMOFONGIN
5-Chloro-8-oxyquinoline
5-chloro-8-quinolino
5-Chloro-8-quinolol
8-Hydroxy-5-chloroquinoline
Chlorisept
Chloroxyquinoline
Cloxyqui
Cloxyquin
Dermofungin
Monochlorohydroxyquinoline
5-CHLORO-8-HYDROXYQUINOLINE CRYSTALLINE
8-Quinolinol, 5-chloro-
Cloxyquine
5-CHLORO-8-QUINOLINOL 99+% | [EINECS(EC#)]
204-978-1 | [Molecular Formula]
C9H6ClNO | [MDL Number]
MFCD00006788 | [Molecular Weight]
179.6 | [MOL File]
130-16-5.mol |
| Chemical Properties | Back Directory | [Appearance]
light green to grey powder | [Melting point ]
122-124 °C(lit.)
| [Boiling point ]
348.7±22.0 °C(Predicted) | [density ]
1.2364 (rough estimate) | [vapor pressure ]
0.003Pa at 25℃ | [refractive index ]
1.5330 (estimate) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
0.019g/l (experimental) | [form ]
Powder | [pka]
3.77±0.10(Predicted) | [color ]
Light green to gray | [Sensitive ]
Light Sensitive | [Merck ]
14,2422 | [BRN ]
5289 | [InChIKey]
RWPWQYXFGFYJBA-UHFFFAOYSA-N | [CAS DataBase Reference]
130-16-5(CAS DataBase Reference) | [NIST Chemistry Reference]
8-Quinolinol, 5-chloro-(130-16-5) | [EPA Substance Registry System]
130-16-5(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [RTECS ]
VC4590000
| [TSCA ]
Yes | [HS Code ]
29334990 |
| Hazard Information | Back Directory | [Chemical Properties]
light green to grey powder | [Uses]
antibacterial, antifungal | [Definition]
ChEBI: Cloxiquine is a member of quinolines and an organochlorine compound. | [Synthesis Reference(s)]
The Journal of Organic Chemistry, 70, p. 8590, 2005 DOI: 10.1021/jo051191x | [in vitro]
Cloxiquine (cloxyquin) exhibits antituberculosis activities, with MICs ranging from 0.062 to 0.25 μg/mL against 9 standard strains and 150 Mycobacterium tuberculosis .
Cloxiquine (0.5-10 μM; 24 h) suppresses both B16F10 and A375 cell growth in a dose-dependent manner.|
Cloxiquine (0.5-10 μM; 24 h) inhibits the migration of B16F10 and A375 cells.
Cloxiquine (0.5-2.5 μM; 24 h) suppresses glycolysis in B16F10 cells. | [in vivo]
Cloxiquine (5-25 mg/kg; i.p. daily for 8 d) suppresses tumor growth in a mouse B16F10 melanoma xenograft model.
Cloxiquine (5-25 mg/kg; i.p. daily for 14 d) suppresses tumor metastasis in mouse B16F10 melanoma lung metastatic model. |
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