| Identification | Back Directory | [Name]
midodrine hydrochloride | [CAS]
133163-28-7 | [Synonyms]
Midodrine (R-isomer HCl)
(R)-Midodrine hydrochloride
Midodrine (R isomer HCl),Midodrine (Risomer HCl)
N-[2-(2,5-Dimethoxyphenyl)-2-hydroxyethyl]glycinamide
Acetamide, 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]-, monohydrochloride, (R)- (9CI) | [MOL File]
133163-28-7.mol |
| Hazard Information | Back Directory | [Uses]
(R)-Midodrine hydrochloride is a vasopressor used as an antihypertensive agent for the treatment of symptomatic postural hypotension, exhibiting peripheral alpha(1)-adrenoreceptor agonistic activity that induces venous and arterial vasoconstriction. | [Definition]
ChEBI: Midodrine is an aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-(glycylamino)-1-hydroxyethyl group. A direct-acting sympathomimetic with selective alpha-adrenergic agonist activity, it is used (generally as its hydrochloride salt) as a peripheral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine. It has a role as a prodrug, an alpha-adrenergic agonist, a sympathomimetic agent and a vasoconstrictor agent. It is a secondary alcohol, an amino acid amide and an aromatic ether. It is functionally related to a glycinamide and a deglymidodrine. It is a conjugate base of a midodrine(1+). | [References]
[1] Chiral investigation of midodrine, a long-acting alpha-adrenergic stimulating agent |
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