| Identification | Back Directory | [Name]
8-M-PDOT | [CAS]
134865-70-6 | [Synonyms]
AH 002
8-M-PDOT
8-METHOXY-2-PROPIONAMIDOTETRALIN | [Molecular Formula]
C14H19NO2 | [MDL Number]
MFCD00901636 | [MOL File]
134865-70-6.mol | [Molecular Weight]
233.31 |
| Chemical Properties | Back Directory | [Boiling point ]
447.8±45.0 °C(Predicted) | [density ]
1.09±0.1 g/cm3(Predicted) | [storage temp. ]
Store at RT | [solubility ]
Soluble to 50 mM in ethanol and to 100 mM in DMSO | [form ]
Powder | [pka]
15.87±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
8-M-PDOT is a melatonin receptor 2 (MT2) agonist (Ki = 1.12 nM). It is 5.2-fold selective for MT2 over MT1 receptors in a radioligand binding assay. Striatal microinfusion of 8-M-PDOT (10 μg/μl) increases the percentage of time spent in the open arms of the elevated plus maze, indicating anxiolytic-like activity, in a rat model of rotenone-induced Parkinson''s disease. | [Uses]
AH 002 is a selective melatonin receptor agonist. | [Biological Activity]
Melatonin receptor agonist, 20-fold selective for the MT 2 (vs MT 1 ) subtype. At human recombinant MT 1 and MT 2 receptors, displays pK i values of 8.23 and 8.95 respectively. |
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| Company Name: |
MedChemExpress
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| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
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