134865-70-6
134865-70-6 结构式
基本信息
中文别名
化合物 T10198 英文别名
AH 0028-M-PDOT
8 M PDOT,8MPDOT
8-METHOXY-2-PROPIONAMIDOTETRALIN
Propanamide, N-(1,2,3,4-tetrahydro-8-methoxy-2-naphthalenyl)-
物理化学性质
沸点447.8±45.0 °C(Predicted)
密度1.09±0.1 g/cm3(Predicted)
储存条件Store at RT
溶解度Soluble to 50 mM in ethanol and to 100 mM in DMSO
酸度系数(pKa)15.87±0.20(Predicted)
形态Powder
颜色White to off-white
常见问题列表
生物活性
8-M-PDOT (AH-002) 是一种选择性的褪黑激素 MT2 受体激动剂。8-M-PDOT 对 MT2 的选择性是 MT1 受体的 5.2 倍。8-M-PDOT 结合人类重组 MT1 和 MT2 受体，其 pKi 值分别为 8.23 和 8.95。8-M-PDOT 具有抗焦虑活性。靶点
pKi: 8.23 (Melatonin MT2 receptor) and 8.95 (Melatonin MT1 receptor)
体内研究
8-M-PDOT (10 µg/µL; administrated into the dorsal striatum by bilateral cannulas; for 30 minutes; male Wistar rats) treatment shows anxiolytic-like effect.
| Animal Model: | Male Wistar rats (280-320 g) with Rotenone |
| Dosage: | 10 µg/µL |
| Administration: | Administrated into the dorsal striatum by bilateral cannulas; for 30 minutes |
| Result: | Increased percentage of time spent in the open arms and in the number of open arms entries. |