| Identification | Back Directory | [Name]
Thio-PEG2-t-butyl ester | [CAS]
1398044-50-2 | [Synonyms]
HS-PEG2-COOtBu
HS-PEG2-CH2CH2COOtBu
SH-PEG2-CH2CH2COOtBu
Thio-PEG2-t-butyl ester
Thiol-PEG2-t-butyl ester
Thiol-PEG2-t-butly ester | [Molecular Formula]
C11H22O4S | [MDL Number]
MFCD22574781 | [MOL File]
1398044-50-2.mol | [Molecular Weight]
250.35 |
| Hazard Information | Back Directory | [Biological Activity]
Thiol-PEG2-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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