| Identification | Back Directory | [Name]
Thiol-PEG6-t-butyl ester | [CAS]
1818294-40-4 | [Synonyms]
HS-PEG6-CH2CH2-Boc
HS-PEG6-CH2CH2COOtBu
SH-PEG6-CH2CH2COOtBu
Thiol-PEG6-t-butyl ester | [Molecular Formula]
C19H38O8S | [MDL Number]
MFCD26127815 | [MOL File]
1818294-40-4.mol | [Molecular Weight]
426.57 |
| Hazard Information | Back Directory | [Biological Activity]
HS-PEG6-CH2CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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