| Identification | More | [Name]
Trimethyl orthoacetate | [CAS]
1445-45-0 | [Synonyms]
1,1,1-TRIMETHOXYETHANE
ORTHOACETIC ACID TRIMETHYL ESTER
TMOA
TRIMETHYL ORTHOACETATE
1,1,1-trimethoxy-ethan
CH3C(OCH3)3
Methyl orthoacetate
trimethyl-acetate
Trimethylorthoaceate
Trimethyl o-acetate
TrimethoxyOrthoAcetate
Ethane, 1,1,1-trimethoxy-
Trimethylorthoacetat
Methylorthoformic acid trimethyl ester | [EINECS(EC#)]
215-892-9 | [Molecular Formula]
C5H12O3 | [MDL Number]
MFCD00008477 | [Molecular Weight]
120.15 | [MOL File]
1445-45-0.mol |
| Chemical Properties | Back Directory | [Appearance]
CLEAR COLOURLESS TO SLIGHTLY BROWN LIQUID | [Boiling point ]
107-109 °C(lit.)
| [density ]
0.944 g/mL at 25 °C(lit.)
| [vapor pressure ]
20 hPa (20 °C) | [refractive index ]
n20/D 1.388(lit.)
| [Fp ]
62 °F
| [storage temp. ]
Flammables area | [form ]
Liquid | [color ]
Clear colorless to slightly brown | [Specific Gravity]
0.960 (20/4℃) | [Water Solubility ]
HYDROLYSIS | [Sensitive ]
Moisture Sensitive | [BRN ]
1098338 | [InChIKey]
HDPNBNXLBDFELL-UHFFFAOYSA-N | [CAS DataBase Reference]
1445-45-0(CAS DataBase Reference) | [NIST Chemistry Reference]
Ethane, 1,1,1-trimethoxy-(1445-45-0) | [EPA Substance Registry System]
1445-45-0(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
F,Xi | [Risk Statements ]
R11:Highly Flammable.
R43:May cause sensitization by skin contact.
R38:Irritating to the skin.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S16:Keep away from sources of ignition-No smoking .
S37/39:Wear suitable gloves and eye/face protection .
S24:Avoid contact with skin .
S33:Take precautionary measures against static discharges .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S7/9:Keep container tightly closed and in a well-ventilated place . | [RIDADR ]
UN 3272 3/PG 2
| [WGK Germany ]
1
| [TSCA ]
Yes | [HazardClass ]
3 | [PackingGroup ]
II | [HS Code ]
29159080 | [Toxicity]
LD50 orally in Rabbit: > 2000 mg/kg |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Sodium Methoxide-->Ethane, (dimethoxymethoxy)--->1-ethoxy-1,1-dimethoxyethane-->METHYL ACETIMIDATE HYDROCHLORIDE-->1,1-DICHLORO-1-NITROETHANE-->1,1-DIMETHOXYETHENE-->Ethane, 1,1'-[(methoxymethylene)bis(oxy)]bis--->trans-Methyl crotonate | [Preparation Products]
4,6-Dimethylpyrimidine-5-carboxylic acid-->Triethyl orthoacetate-->Methyl 3,3-dimethylpent-4-enoate-->Methyl N-cyanoethanimideate-->N-TERT-BUTYLACETAMIDE-->METHYL 2-CHLORO-3-NITROBENZOATE-->Methyl 2,6-dimethoxybenzoate-->EthaniMidaMide, N,N'-bis(1-Methylethyl)--->DODECYL ACETATE-->N-Isopropylacetamide-->Ganciclovir Mono-O-acetate |
| Hazard Information | Back Directory | [Chemical Properties]
CLEAR COLOURLESS TO SLIGHTLY BROWN LIQUID | [Uses]
Trimethyl orthoacetate has been used in the preparation of 2-amino-9-(3-acyloxymethyl-4-alkoxycarbonyloxybut-1-yl)purines and 2-amino-9-(3-alkoxycarbonyl-oxymethyl-4-alkoxycarbonyloxybut -1-yl)purines. | [General Description]
Kinetics and mechanism of gas-phase elimination of trimethyl orthoacetate has been examined over the temperature range of 310-369°C and pressure range of 50-130Torr. |
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