| Identification | Back Directory | [Name]
OMEGA-AGATOXIN TK | [CAS]
145017-83-0 | [Synonyms]
Snx 290
ω-aga-tk
OMEGA-AGA-TK
ω-agatoxin tk
OMEGA-AGA-IVB
o-Agatoxin IVa
Ω-AGATOXIN IVA
OMEGA-AGATOXIN TK
OMEGA-AGATOXIN TK (P-TYPE BLOCKER)
OMEGA-AGATOXIN TK, AGELENOPSIS APERTA
Omega-agatoxin iv A (funnel-web spider venom)
Omega-agatoxin iva (reduced), cyclic (4-20),(12-25),(19-36),(27-34)-tetrakis(disulfide)
GLU-ASP-ASN-CYS-ILE-ALA-GLU-ASP-TYR-GLY-LYS-CYS-THR-TRP-GLY-GLY-THR-LYS-CYS-CYS-ARG-GLY-ARG-PRO-CYS-ARG-CYS-SER-MET-ILE-GLY-THR-ASN-CYS-GLU-CYS-THR-PRO-ARG-LEU-ILE-MET-GLU-GLY-LEU-D-SER-PHE-ALA
H-Lys-Lys-Lys-Cys-Ile-Ala-Lys-Asp-Tyr-Gly-Arg-Cys-Lys-Trp-Gly-Gly-Thr-Pro-Cys-Cys-Arg-Gly-Arg-Gly-Cys-Ile-Cys-Ser-Ile-Met-Gly-Thr-Asn-Cys-Glu-Cys-Lys-Pro-Arg-Leu-Ile-Met-Glu-Gly-Leu-Gly-Leu-Ala-OH
Omega-Agatoxin IVa trifluoroacetate salt H-Lys-Lys-Lys-Cys-Ile-Ala-Lys-Asp-Tyr-Gly-Arg-Cys-Lys-Trp-Gly-Gly-Thr-Pro-Cys-Cys-Arg-Gly-Arg-Gly-Cys-Ile-Cys-Ser-Ile-Met-Gly-Thr-Asn-Cys-Glu-Cys-Lys-Pro-Arg-Leu-Ile-Met-Glu-Gly-Leu-Gly-Leu-Ala-OH trifluoroacetate salt (Disulfide bonds between Cys4 and Cys20/Cys12 and Cys25/Cys19 and Cys36/Cys27 and Cys34) | [Molecular Formula]
C215H337N65O70S10 | [MDL Number]
MFCD00286234 | [Molecular Weight]
5273.02 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
H2O: Aqueous stock solution is stable for 1 month at 2-8?#x00b0;C and for several months at -20?#x00b0;C.soluble
| [form ]
powder
| [Water Solubility ]
Soluble in water |
| Hazard Information | Back Directory | [Uses]
omega-Agatoxin TK is a selective blocker of the P-type Ca2+?channel. | [Uses]
ω-Agatoxin IVA has been used in the manipulation of calcium influx. It has also been used in the study to characterize the spontaneous and evoked activity from murine ventral horn cultures on microelectrode arrays. | [General Description]
CACNA1A (calcium voltage-gated channel subunit alpha1 A)?gene codes for the α1 subunit of neuronal CaV2.1 (P/Q-type) voltage-gated calcium channels. It is expressed throughout the central nervous system (CNS). CACNA1A gene is located on human chromosome 19p13. | [Biochem/physiol Actions]
Toxin found in the venom of the funnel web spider, Agelenopsis aptera. Potent, selective blocker of mammalian P-type voltage-dependent calcium channels. | [storage]
-20°C (desiccate) |
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Sigma-Aldrich
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021-61415566 800-8193336 |
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https://www.sigmaaldrich.cn |
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