ChemicalBook--->CAS DataBase List--->146672-58-4

146672-58-4

146672-58-4 Structure

146672-58-4 Structure
IdentificationBack Directory
[Name]

PAPA NONOATE
[CAS]

146672-58-4
[Synonyms]

NOC-15
PAPA/NO
PAPA NONATE
PAPA NONOATE
NOC-15 NONOATE
PROPYLAMINE PROPYLAMINE NONOATE
3-[[nitroso(oxido)amino]-propylamino]propylazanium
1-HYDROXY-2-OXO-3-(3-AMINOPROPYL)-3-PROPYL-1-TRIAZENE
3-(2-hydroxy-2-nitroso-1-propylhydrazino)-1-propanamine
1-Propanamine, 3-(2-hydroxy-2-nitroso-1-propylhydrazinyl)-
3-(2-HYDROXY-2-NITROSO-1-PROPYLHYDRAZINO)-1-PROPANAMINE NONOATE
3-(2-Hydroxy-2-nitroso-1-propylhydrazino)-1-propanamine, NOC-15
(Z)-1-[N-(3-AMINOPROPYL)-N-)B-PROPYL)AMINO]DIAZIN-1-IUM-1,2-DIOLATE
(Z)-1-[N-(3-AMMONIOPROPYL)-N-(N-PROPYL)AMINO]DIAZEN-1-IUM-1,2-DIOLATE
[Molecular Formula]

C6H16N4O2
[MDL Number]

MFCD00801020
[MOL File]

146672-58-4.mol
[Molecular Weight]

176.22
Chemical PropertiesBack Directory
[storage temp. ]

-20°C
[solubility ]

Soluble in Water or Ethanol.
[form ]

White to off-white solid.
[color ]

Off-white
[Stability:]

Stable for 1 year from date of purchase as supplied. Protect from exposure to air or moisture. Solutions are not stable and must be prepared immediately before use.
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302
[Precautionary statements ]

P264-P270-P301+P312-P330-P501
[Hazard Codes ]

Xn
[Risk Statements ]

22
Hazard InformationBack Directory
[Description]

PAPA NONOate (146672-58-4) is a nitric oxide donor and dissociates to the free amine and NO in a pH dependent manner. The half-life of PAPA NONOate in 0.1 M phosphate buffer at pH 7.4 is 15 minutes at 37°C, or 77 minutes at room temperature.1?Dissociation is essentially instantaneous at a pH of 5.0.
[Uses]

PAPA NONOate is an NO donor which suppresses the caspase apoptotic cascade.
[Definition]

ChEBI: PAPA NONOate is an alkylamine.
[References]

1) Keefer?et al. (1996),?‘NONOates’ (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: Convenient nitric oxide dosage forms; Methods Enzymol.,?268?281
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