| Identification | Back Directory | [Name]
NOC-18 | [CAS]
146724-94-9 | [Synonyms]
NOC-18
DETA/NO
DETA NONOATE
DETA NONOate,97%
DETA-NONOate,NOC-18
NOC 18, DETA NONOate,
DIETHYLENETRIAMINE NONOATE
2,2'-(HYDROXYNITROSOHYDRAZINO)BIS-ETHAMINE
2,2'-(HYDROXYNITROSOHYDRAZINO)BIS-ETHANAMINE
1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane
3,3-BIS(AMINOETHYL)-1-HYDROXY-2-OXO-1-TRIAZENE
1-HYDROXY-2-OXO-3,3-BIS(3-AMINOETHYL)-1-TRIAZENE
2,2μ-(Hydroxynitrosohydrazono)bis-ethanimine, DETA/NO
2,2μ-(Hydroxynitrosohydrazino)bis-ethanamine, DETA NONOate, NOC-18
(Z)-1-[N-(2-AMINOETHYL)-N-(2-AMMONIOETHYL)AMINO]DIAZEN-1-IUM-1,2-DIOLATE
(Z)-1-[2-(2-AMINOETHYL)-N-(2-AMMONIOETHYL)AMINO]DIAZEN-1-IUM-1,2-DIOLATE | [Molecular Formula]
C4H13N5O2 | [MDL Number]
MFCD00278808 | [MOL File]
146724-94-9.mol | [Molecular Weight]
163.18 |
| Chemical Properties | Back Directory | [Appearance]
White Powder | [Melting point ]
98-106 °C
| [Boiling point ]
290.26°C (rough estimate) | [density ]
1.3102 (rough estimate) | [refractive index ]
1.8000 (estimate) | [storage temp. ]
−20°C
| [solubility ]
H2O: >20 mg/mL
| [form ]
solid
| [pka]
4.50±0.69(Predicted) | [color ]
off-white
| [Water Solubility ]
PBS, pH 7.4: 100mg/mL
10 mM NaOH: soluble
water: soluble | [Stability:]
Stable for 1 year from date of purchase as supplied. Store under inert gas. Solutions must be made fresh immediately before use and cannot be stored. | [CAS DataBase Reference]
146724-94-9 |
| Hazard Information | Back Directory | [Chemical Properties]
White Powder | [Uses]
A stable NO-amine complex which can release NO spontaneously under physiological conditions. The half life of NO release in 0.1 M PBS at (pH7.4) at 37?C for 0.1mM NOC 5 is 21 hours.
Other applications include the induction of dose dependent apoptosis in macrophages, and inhibition of lipoprotein oxidation induced by Cu2+ in vitro. | [Definition]
ChEBI: A nitroso compound that is triazane in which the the nitrogen at position 1 is substituted by two 2-aminoethyl groups, that at position 2 is substituted by a hydroxy group, and that at position 3 is substituted by an oxo group. | [Description]
DETA NONOate (146724-94-9) is a nitric oxide donor and dissociates to the free amine and NO in a pH dependent manner. The half-life of DETA NONOate in 0.1 M phosphate buffer at pH 7.4 is 20 hours at 37°C, or 56 hours at room temperature.1?Dissociation is essentially instantaneous at a pH of 5.0. | [Biochem/physiol Actions]
3,3-Bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene is a long-acting nitric oxide donor. It might exhibit nociceptive effects in rats. | [storage]
Store at -80°C, protect from light | [References]
1) Keefer?et al. (1996),?‘NONOates’ (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: Convenient nitric oxide dosage forms; Methods Enzymol.,?268?281 |
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