ChemicalBook--->CAS DataBase List--->1544-86-1

1544-86-1

1544-86-1 Structure

1544-86-1 Structure
IdentificationMore
[Name]

4-(DIFLUOROMETHOXY)NITROBENZENE
[CAS]

1544-86-1
[Synonyms]

1-(DIFLUOROMETHOXY)-4-NITROBENZENE
4-(DIFLUOROMETHOXY)NITROBENZENE
4-NITRO-ALPHA,ALPHA-DIFLUOROANISOLE
BUTTPARK 45\10-48
Anisole,α,α-difluoro-p-nitro-
Benzene,1-(difluoromethoxy)-4-nitro-
Difluoromethyl4-nitrophenylether
p-Nitrophenyldifluoromethylether
α,α-Difluoro-p-nitroanisole
4-(Difluoromethoxy)nitrobenzen, 98%
4-(Difluoromethoxy)nitrobenzene98%
[Molecular Formula]

C7H5F2NO3
[MDL Number]

MFCD00085009
[Molecular Weight]

189.12
[MOL File]

1544-86-1.mol
Chemical PropertiesBack Directory
[Melting point ]

37-40 °C (lit.)
[Boiling point ]

108 °C
[density ]

1.384±0.06 g/cm3(Predicted)
[Fp ]

>230 °F
[storage temp. ]

2-8°C
[CAS DataBase Reference]

1544-86-1(CAS DataBase Reference)
Safety DataBack Directory
[Hazard Codes ]

Xn,Xi
[Risk Statements ]

R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin .
[Safety Statements ]

S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37:Wear suitable protective clothing and gloves .
[RIDADR ]

3276
[WGK Germany ]

3
[Hazard Note ]

Irritant
[HazardClass ]

IRRITANT
[HS Code ]

29049090
Hazard InformationBack Directory
[Chemical Properties]

Pale Yellow Crystal.
[Uses]

4-(Difluoromethoxy)nitrobenzene is an industrial chemical that can be used to make 4-fluoro-3-pyridinol (F3P), a compound that has potential as a new drug for the treatment of cancer. The synthesis of F3P begins with the reaction of 4-(difluoromethoxy)nitrobenzene and potassium hydroxide in methanol, which yields 4-fluoro-3-hydroxypyridine. This product is then reacted with ammonia gas and pyridine to yield F3P. The final step involves heating the product at high temperature with nitric acid, which yields nitrobenztriazole.
[General Description]

4-(Difluoromethoxy)nitrobenzene (1-(difluoromethoxy)-4-nitrobenzene) can be synthesized by reacting 4-nitrophenol with KOH, water and methanol.
Spectrum DetailBack Directory
[Spectrum Detail]

4-(DIFLUOROMETHOXY)NITROBENZENE(1544-86-1)MS
4-(DIFLUOROMETHOXY)NITROBENZENE(1544-86-1)1HNMR
4-(DIFLUOROMETHOXY)NITROBENZENE(1544-86-1)13CNMR
4-(DIFLUOROMETHOXY)NITROBENZENE(1544-86-1)IR1
4-(DIFLUOROMETHOXY)NITROBENZENE(1544-86-1)IR2
Well-known Reagent Company Product InformationBack Directory
[Alfa Aesar]

1-Difluoromethoxy-4-nitrobenzene, 98%(1544-86-1)
[Sigma Aldrich]

1544-86-1(sigmaaldrich)
[TCI AMERICA]

4-(Difluoromethoxy)nitrobenzene,>98.0%(GC)(1544-86-1)
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