| Identification | Back Directory | [Name]
4-PREGNEN-6-BETA, 17,21-TRIOL-3,11,20-TRIONE | [CAS]
16355-28-5 | [Synonyms]
NSC15457
6β-Hydroxycortisone
6-BETA-HYDROCORTISONE
6-BETA-HYDROXYCORTISONE
6B-hydroxycortisone approx. 99%
4-Pregnene-6β,17α,21-triol-3,11,20-trione
4-PREGNEN-6-β, 17,21-TRIOL-3,11,20-TRIONE
4-PREGNEN-6-BETA, 17,21-TRIOL-3,11,20-TRIONE
6β,17,21-Trihydroxypregna-4-ene-3,11,20-trione
6β,17α,21-Trihydroxypregn-4-ene-3,11,20-trione
4-PREGNEN-6BETA,17ALPHA,21-TRIOL-3,11,20-TRIONE
4-PREGNENE-6-BETA,17-ALPHA,21-TRIOL-3,11,20-TRIONE
Pregn-4-ene-3,11,20-trione, 6,17,21-trihydroxy-, (6β)-
6-BETA,17-ALPHA,21-TRIHYDROXY-4-PREGNENE-3,11,20-TRIONE
(6R,8S,9S,10R,13S,14S,17R)-6,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthrene-3,11-dione
(6R,8S,9S,10R,13S,14S,17R)-6,17-Dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-7,8,9,10,12,13,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthrene-3,11(2H,6H)-dione | [Molecular Formula]
C21H28O6 | [MDL Number]
MFCD00057669 | [MOL File]
16355-28-5.mol | [Molecular Weight]
376.44 |
| Hazard Information | Back Directory | [Uses]
6β-Hydroxycortisone-d7 is the isotope labelled analog of 6β-Hydroxycortisone (H918450); a compound that can be used as a probe to detect inhibition of CYP3A4 in vivo. | [Definition]
ChEBI: 6beta-hydroxycortisone is a C21-steroid that is cortisone bearing an additional hydroxy substituent at the 6beta-position. It is produced as a metabolite of cortisol by cytochrome p450-3A4 (CYP3A4, an important enzyme involved in the metabolism of a variety of exogenous and endogenous compounds) and can be used to detect moderate and potent CYP3A4 inhibition in vivo. It has a role as a probe and a human metabolite. It is a C21-steroid, a 6beta-hydroxy steroid, a 3-oxo-Delta(4) steroid, a 21-hydroxy steroid, a 20-oxo steroid, a 17alpha-hydroxy steroid, an 11-oxo steroid, a primary alpha-hydroxy ketone and a tertiary alpha-hydroxy ketone. It is functionally related to a cortisone. |
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