| Identification | Back Directory | [Name]
2-Naphthalenecarboxamide, N-[2-[4-oxo-1-(3-pyridinylmethyl)-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]- | [CAS]
1638957-17-1 | [Synonyms]
ML395
ML-395
ML 395
VU0468809
VU-0468809
VU 0468809
2-Naphthalenecarboxamide, N-[2-[4-oxo-1-(3-pyridinylmethyl)-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]- | [Molecular Formula]
C26H29N5O2 | [MDL Number]
MFCD28502199 | [MOL File]
1638957-17-1.mol | [Molecular Weight]
443.54 |
| Hazard Information | Back Directory | [Description]
ML395, also known as VU0468809, is a potent PLD2 inhibitor. ML39 showed potent antiviral activity. ML395 (VU0468809), a potent, >80-fold PLD2 selective allosteric inhibitor (cellular PLD1, IC50 >30,000 nM; cellular PLD2, IC50 =360 nM). Moreover, ML395 possesses an attractive in vitro DMPK profile, improved physiochemical properties, ancillary pharmacology (Eurofins Panel) cleaner than any other reported PLD inhibitor, and has been found to possess interesting activity as an antiviral agent in cellular assays against a range of influenza strains (H1, H3, H5 and H7). |
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