1638957-17-1

中文名称 2-Naphthalenecarboxamide, N-[2-[4-oxo-1-(3-pyridinylmethyl)-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]-

英文名称 2-Naphthalenecarboxamide, N-[2-[4-oxo-1-(3-pyridinylmethyl)-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]-

CAS 1638957-17-1

分子式 C26H29N5O2

分子量 443.54

MOL 文件 1638957-17-1.mol

1638957-17-1 结构式

基本信息应用领域

基本信息

中文别名

化合物 T28071

英文别名

ML395
ML-395
ML 395
VU0468809
VU-0468809
VU 0468809
2-Naphthalenecarboxamide, N-[2-[4-oxo-1-(3-pyridinylmethyl)-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]-

应用领域

用途一

ML395, also known as VU0468809, is a potent PLD2 inhibitor. ML39 showed potent antiviral activity. ML395 (VU0468809), a potent, >80-fold PLD2 selective allosteric inhibitor (cellular PLD1, IC50 >30,000 nM; cellular PLD2, IC50 =360 nM). Moreover, ML395 possesses an attractive in vitro DMPK profile, improved physiochemical properties, ancillary pharmacology (Eurofins Panel) cleaner than any other reported PLD inhibitor, and has been found to possess interesting activity as an antiviral agent in cellular assays against a range of influenza strains (H1, H3, H5 and H7).