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171202-16-7

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171202-16-7 Structure

171202-16-7 Structure
IdentificationBack Directory
[Name]

bpV(phen) (potassium hydrate)
[CAS]

171202-16-7
[Synonyms]

bpV(phen) trihydrate
bpV(phen) (potassium hydrate)
Bisperoxovanadium (Bisperoxovanadium(phen)
[Molecular Formula]

C12H14KN2O8V
[MDL Number]

MFCD28053521
[MOL File]

171202-16-7.mol
[Molecular Weight]

404.288
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: 1 mg/ml; PBS (pH 7.2): 10 mg/ml
[form ]

A crystalline solid
[color ]

Yellow to orange
Hazard InformationBack Directory
[Description]

bpV(phen) is a bisperoxovanadium (bpV) compound which inhibits several different protein tyrosine phosphatases (PTPs), with selectivity for PTEN (IC50 = 38 nM). It also inhibits the vascular endothelial PTP, PTP-β (IC50 = 343 nM), and PTP-1β (IC50 = 920 nM). At 0.1 mM, bpV(phen) inhibits SH2 domain-containing inositol 5’-phosphatase-2. Presumably by inhibiting insulin receptor kinase-associated PTPs, bpV(phen) activates the insulin receptor tyrosine kinase and promotes downstream signaling, including activation of PI3-kinase.
[Uses]

bpV(phen) (Potassium Hydrate) inhibits several different protein tyrosine phosphatases (PTPs).
[storage]

Store at -20°C
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