171202-16-7

中文名称 bpV(phen) (potassium hydrate)

英文名称 bpV(phen) (potassium hydrate)

CAS 171202-16-7

分子式 C12H14KN2O8V

分子量 404.288

MOL 文件 171202-16-7.mol

更新日期 2023/03/20 15:41:25

171202-16-7 结构式

基本信息物理化学性质 bpV(phen) (potassium hydrate)价格(试剂级) 常见问题列表

基本信息

英文别名

bpV(phen) trihydrate
bpV(phen) (potassium hydrate)
Bisperoxovanadium (Bisperoxovanadium(phen)

物理化学性质

储存条件-20°C储存

溶解度DMSO: 1 mg/ml; PBS (pH 7.2): 10 mg/ml

形态结晶固体

颜色Yellow to orange

bpV(phen) (potassium hydrate)价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2024/04/30	HY-122818	bpV(phen) (potassium hydrate) bpV(phen) trihydrate	171202-16-7	5mg	650元
2024/04/30	HY-122818	bpV(phen) (potassium hydrate) bpV(phen) trihydrate	171202-16-7	10mg	1050元
2024/04/30	HY-122818	bpV(phen) (potassium hydrate) bpV(phen) trihydrate	171202-16-7	25mg	1950元

常见问题列表

生物活性

bpV(phen) trihydrate，一种胰岛素模拟物，是一种有效的蛋白酪氨酸磷酸酶 (PTP) 和 PTEN 抑制剂，对 PTEN，PTP-β 和 PTP-1B 的 IC50 为 38 nM，343 nM 和 920 nM。bpV(phen) trihydrate 在体外抑制原生动物寄生虫利什曼原虫的增殖。bpV(phen) trihydrate 强烈诱导大量趋化因子和促炎性细胞因子的分泌，并激活 Th1 型途径 (IL-12，IFNγ)。bpV(phen) trihydrate 还可以诱导细胞凋亡 (apoptosis)，并具有抗血管生成和抗肿瘤活性。

靶点

IC50: 38 nM (PTEN), 343 nM (PTP-β) and 920 nM (PTP-1B)
Parasite Leishmania
Apoptosis

体外研究

bpV(phen) (5 μM; 24.5 hours; H9c2 cells) treatment causes a further decrease of cell viability in H/R-injured H9c2 cells.
bpV(phen) (5 μM; 24.5 hours; H9c2 cells) treatment increases the apoptosis of H/R-injured H9c2 cells.
bpV(phen) (5 μM; 24.5 hours; H9c2 cells) treatment significantly promotes the accumulation of cytoplasmic Cytochrome C in H/R-injured H9c2 cells.
After stimulation of bpV(phen), PTEN-induced putative kinase protein 1 (PINK1)/Parkin-mediated mitophagy is inhibited.
bpV(phen) is an insulin-mimetic agent following insulin-receptor tyrosine kinase hyperphosphorylation and activation.

Cell Viability Assay

Cell Line:	Hypoxia/reoxygenation (H/R)-injured H9c2 cells
Concentration:	5 μM
Incubation Time:	24.5 hours (hypoxia for 24 h; reoxygenation for 30 minutes)
Result:	Caused a further decrease of cell viability.

Apoptosis Analysis

Cell Line:	Hypoxia/reoxygenation (H/R)-injured H9c2 cells
Concentration:	5 μM
Incubation Time:	24.5 hours (hypoxia for 24 h; reoxygenation for 30 minutes)
Result:	Increased the apoptosis of H/R-injured H9c2 cells.

Western Blot Analysis

Cell Line:	Hypoxia/reoxygenation (H/R)-injured H9c2 cells
Concentration:	5 μM
Incubation Time:	24.5 hours (hypoxia for 24 h; reoxygenation for 30 minutes)
Result:	Showed an increased release of Cytochrome C.

体内研究

bpV(phen) (5 mg/kg; intraperitoneal injection; daily; for 38 days; male BALB/c nude (nu/nu) athymic mice) treatment causes a significant reduction in average tumor volume.

Animal Model:	Male BALB/c nude (nu/nu) athymic mice (6-7 weeks old) injected with PC-3 cells
Dosage:	5 mg/kg
Administration:	Intraperitoneal injection; daily; for 38 days
Result:	Caused a significant reduction in average tumor volume.