| Identification | Back Directory | [Name]
LEPTIN, HUMAN | [CAS]
177404-21-6 | [Synonyms]
ARH6
ARHB
RHOB
rHuL
LEPTIN
MST081
HUMAN OB
OB HUMAN
HUMAN LEPTIN
LEPTIN, HUMAN
Rho cDNA clone 6
Leptin (human) 146
REC LEPTIN (HUMAN)
HUMAN OBESITY PROTEIN
Leptin, Human, Recomb.
OB GENE PRODUCT (HUMAN)
Mouse Anti Human Leptin
RECOMBINANT HUMAN LEPTIN
REC OBESE PROTEIN (HUMAN)
REC OBESITY FACTOR (HUMAN)
OBESE GENE PRODUCT (HUMAN)
Rabbit Anti-Leptin antibody
LEPTIN (HUMAN) (RECOMBINANT)
Leptin, Human, Recombinant, E. coli
Rho-related GTP-binding protein RhoB
Recombinant Goldfish Leptin Protein, His Tag
ANTI-ARHB (CENTER) antibody produced in rabbit
LEPTIN, HUMAN RECOMBINANT EXPRESSED IN E . COLI
rec Obese Protein (huMan), rec Obesity Factor (huMan) | [MDL Number]
MFCD01094205 |
| Questions And Answer | Back Directory | [Structure]
Leptin is produced as a 167-aa residue preprohormone,
including an N-terminal 21-aa signal peptide,
and is released as a 146-aa peptide after enzymatic
cleavage. | [Properties]
Human leptin: Mr 16,000, pI 5.8. Leptin is soluble in
water. | [Uses]
Leptin analogs are used for the treatment of lipodystrophy
in clinical settings. | [Gene, mRNA, and precursor]
The human leptin gene, LEP, location 7q31.3, consists
of three exons. Human leptin mRNA has a 3.5kb length
that encodes a signal peptide of 21 aa residues and a
mature protein of 146 aa residues. | [Regulation of synthesis and release]
The synthesis and release of leptin are regulated by
environmental factors. In humans and rodents, obesity
stimulates leptin synthesis and increases the plasma
concentrations. Exercise decreases the plasma leptin concentrations
in the rat. Exposure to low temperature suppresses
leptin gene expression in WAT and reduces the
plasma leptin concentrations in rodents. While fasting
attenuates leptin gene expression, feeding restores the
levels of gene expression. |
| Hazard Information | Back Directory | [Description]
Leptin is an adipocyte hormone secreted from white adipose
tissues that regulates energy expenditure and food intake
by acting on receptors located in the hypothalamus. |
|
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