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177987-04-1

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177987-04-1 Structure

177987-04-1 Structure
IdentificationBack Directory
[Name]

Br-PEG7-Br
[CAS]

177987-04-1
[Synonyms]

Br-PEG7-Br
CAS_177987-04-1
Br-PEG7-CH2CH2Br
Bromo-PEG8-bromide
1,23-dibromo-3,6,9,12,15,18,21-heptaoxatricosane
3,6,9,12,15,18,21-Heptaoxatricosane, 1,23-dibromo-
[Molecular Formula]

C16H32Br2O7
[MDL Number]

MFCD29917793
[MOL File]

177987-04-1.mol
[Molecular Weight]

496.23
Chemical PropertiesBack Directory
[Boiling point ]

486.9±40.0 °C(Predicted)
[density ]

1.364±0.06 g/cm3(Predicted)
[form ]

Liquid
[color ]

Colorless to light yellow
Hazard InformationBack Directory
[Biological Activity]

Br-PEG7-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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