| Identification | Back Directory | [Name]
Br-PEG7-OH | [CAS]
86220-35-1 | [Synonyms]
Br-PEG7-OH
20-Bromo-3,6,9,12,15,18-hexaoxaicosan-1-ol | [Molecular Formula]
C14H29BrO7 | [MDL Number]
MFCD31656971 | [MOL File]
86220-35-1.mol | [Molecular Weight]
389.28 |
| Chemical Properties | Back Directory | [Boiling point ]
443.0±40.0 °C(Predicted) | [density ]
1.261±0.06 g/cm3(Predicted) | [form ]
Liquid | [pka]
14.36±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Biological Activity]
Bromo-PEG7-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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