| Identification | Back Directory | [Name]
EFT-508 | [CAS]
1849590-01-7 | [Synonyms]
EFT-508
CS-2450
eFT508 -MNK
Tomivosertib
eFT-508 (eFT508)
Tomivosertib eFT508
eFT508(Tomivosertib)
EFT 508;EFT-508;TOMIVOSERTIB
6-[(6-aminopyrimidin-4-yl)amino]-8-methylspiro[2H-imidazo[1,5-a]pyridine-3,1'-cyclohexane]-1,5-dione
6'-[(6-Amino-4-pyrimidinyl)amino]-8'-methylspiro[cyclohexane-1,3'(2'H)-imidazo[1,5-a]pyridine]-1',5'-dione
Spiro[cyclohexane-1,3'(2'H)-imidazo[1,5-a]pyridine]-1',5'-dione, 6'-[(6-amino-4-pyrimidinyl)amino]-8'-methyl-
6'-((6-aminopyrimidin-4-yl)amino)-8'-methyl-1'H-spiro[cyclohexane-1,3'-imidazo[1,5-a]pyridine]-1',5'(2'H)-dione | [Molecular Formula]
C17H20N6O2 | [MDL Number]
MFCD30489732 | [MOL File]
1849590-01-7.mol | [Molecular Weight]
340.38 |
| Chemical Properties | Back Directory | [Melting point ]
>300°C | [Boiling point ]
735.6±60.0 °C(Predicted) | [density ]
1.43±0.1 g/cm3(Predicted) | [storage temp. ]
Refrigerator, under inert atmosphere | [solubility ]
DMSO (Slightly, Heated), Methanol (Very Slightly) | [form ]
Solid | [pka]
13.77±0.60(Predicted) | [color ]
Pale Yellow |
| Hazard Information | Back Directory | [Description]
eFT508 is a potent inhibitor of MAPK interacting protein kinases (MNK) 1 and 2 (IC50s = <10 nM). It inhibits phosphorylation of eukaryotic initiation factor 4E (eIF4E) with an IC50 value of <50 nM in a cellular signaling assay. eFT508 has a half-life of 5.3 hours in rats. | [Uses]
6''-[(6-Amino-4-pyrimidinyl)amino]-8''-methylspiro[cyclohexane-1,3''(2''H)-imidazo[1,5-a]pyridine]-1'',5''-dione was used in the study of inhibitors of immune checkpoint modulators and related methods. eFT508 is a potent, highly selective, and orally bioavailable MNK1 and MNK2 inhibitor. |
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| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
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