| Identification | Back Directory | [Name]
CS-003 Free base | [CAS]
191672-52-3 | [Synonyms]
CS-003 Free base
Methanone, [(2R)-2-(3,4-dichlorophenyl)-2-[2-[(2S)-2-oxidospiro[benzo[c]thiophene-1(3H),4'-piperidin]-1'-yl]ethyl]-4-morpholinyl](3,4,5-trimethoxyphenyl)- | [Molecular Formula]
C34H38Cl2N2O6S | [MDL Number]
MFCD32197314 | [MOL File]
191672-52-3.mol | [Molecular Weight]
673.65 |
| Chemical Properties | Back Directory | [Boiling point ]
846.5±65.0 °C(Predicted) | [density ]
1.41±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
8.69±0.20(Predicted) |
| Hazard Information | Back Directory | [Biological Activity]
CS-003 Free base (CS-003) is a tritachykinin receptor antagonist with high affinity for human neurokinin NK1, NK2 and NK3 receptors with Ki values of 2.3 nM and 0.54 nM, respectively and 0.74 nM.It can be used in the study of neurokinin-related respiratory diseases. | [in vitro]
CS-003 (0.01-10 μM; 24 hours) inhibits NK1, NK2 or NK3 induced inositol phosphate formation in a concentration-dependent manner with pA2 values of 8.7, 9.4 and 9.5 μM, respectively. | [in vivo]
CS-003 (intravenous injection; 0.01-3.0 mg/kg; 5 min before neurokinin A/B/C injection) inhibits substance P-induced tracheal vascular hyperpermeability, neurokinin A- and neurokinin B-induced bronchoconstriction with ID 50 values of 0.13, 0.040 and 0.063 mg/kg, respectively. | [target]
| NK1 2.3 nM (Ki) | NK2 0.54 nM (Ki) | NK3 0.74 nM (Ki) | < /table>
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| Company Name: |
cjbscvictory
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| Tel: |
13348960310 13348960310 |
| Website: |
http://www.weikeqi-biotech.com/ |
| Company Name: |
MedChemExpress
|
| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
|
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Tags:191672-52-3
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