| Identification | Back Directory | [Name]
Propargyl-PEG1-SS-PEG1-propargyl | [CAS]
1964503-40-9 | [Synonyms]
Propargyl-PEG1-SS-PEG1-propargyl
Disulfide, bis[2-(2-propyn-1-yloxy)ethyl]-
1,2-bis(2-(prop-2-yn-1-yloxy)ethyl)disulfane | [Molecular Formula]
C10H14O2S2 | [MDL Number]
MFCD30182027 | [MOL File]
1964503-40-9.mol | [Molecular Weight]
230.35 |
| Hazard Information | Back Directory | [Description]
Propargyl-PEG1-SS-PEG1-propargyl is a homoebifunctional cleavable PEG linker containing two propargyl groups and a disulfide bond. The propargyl group can be reacted with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. Disulfide bond cn be cleaved with reducing agent. | [Uses]
Propargyl-PEG1-SS-PEG1-propargyl is a cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Propargyl-PEG1-SS-PEG1-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
Disulfide Cleavable Linker; Cleavable Linker | [References]
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
|
|