| Identification | More | [Name]
2-AMINO-2-NORBORNANECARBOXYLIC ACID | [CAS]
20448-79-7 | [Synonyms]
BCH
B-Bch
LAT1-IN-1
LAT1-IN-1 (BCH)
2-Aminonorbornane-2-carboxylic acid
2-AMINO-2-NORBORNANECARBOXYLIC ACID
2-Amino-2-carboxy-bicyclo-2,2,1-heptane
2-AMINOBICYCLO[2.2.1]HEPTANE-2-CARBOXYLIC ACID
3-amino-3-bicyclo[2.2.1]heptanecarboxylic acid
3-aminobicyclo[2.2.1]heptane-3-carboxylic Acid
Bicyclo(2.2.1)heptane-2-carboxylic acid, 2-amino-
2-AMINO-2-NORBORNANECARBOXYLIC ACID, 98% , MIXTURE OF ISOMERS
2-AMino-2-norbornanecarboxylic acid aMino acid transport inhibitor | [Molecular Formula]
C8H13NO2 | [MDL Number]
MFCD00167580 | [Molecular Weight]
155.19 | [MOL File]
20448-79-7.mol |
| Chemical Properties | Back Directory | [Melting point ]
>300 °C(lit.) | [Boiling point ]
295.5±23.0 °C(Predicted) | [density ]
1.256±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
Aqueous Acid (Slightly) | [form ]
Solid | [pka]
2.58±0.20(Predicted) | [color ]
White | [Water Solubility ]
Soluble to 100 mM in water | [CAS DataBase Reference]
20448-79-7(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Uses]
2-Amino-2-norbornanecarboxylic Acid functions in the suppressive effect of I-type amino acid transporter 1 inhibition as therapeutic target on human esophageal squamous cell carcinoma. Also use in the design and preparation of KMH-233, selective and slowly reversible inhibitor of L-type amino acid transporter 1 (LAT1) which potentiates antiproliferative drug efficacy in cancer cells | [Definition]
ChEBI: 2-Amino-2-norbornanecarboxylic acid is a monoterpenoid. | [General Description]
2-Amino-2-norbornanecarboxylic acid is a potential large amino acid transporters inhibitor. It may suppress tumor progression and apoptosis. | [Biochem/physiol Actions]
2-Amino-2-norbornanecarboxylic acid (BCH) is a Na(+)-independent system L specific substrate used with other system specific substrates such as the system A specific substrate α-(methylamino) isobutyric acid and system N specific substrate L-glutamic acid gamma-monohydroxamate to help identify, differentiate and characterize amino acid transport systems in cells. | [storage]
Store at RT |
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Sigma-Aldrich
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