| Identification | Back Directory | [Name]
(2R)-2-({[3,5-bis(trifluoromethyl)phenyl]carbamothioyl}amino)-N-(2,4-difluorophenyl)-2-phenylacetamide | [CAS]
2101517-69-3 | [Synonyms]
BL 918 NEW
BL-918
(BL918)
(2R)-2-({[3,5-bis(trifluoromethyl)phenyl]carbamothioyl}amino)-N-(2,4-difluorophenyl)-2-phenylacetamide | [EINECS(EC#)]
825-946-9 | [Molecular Formula]
C23H15F8N3OS | [MDL Number]
MFCD31693829 | [MOL File]
2101517-69-3.mol | [Molecular Weight]
533.437 |
| Questions And Answer | Back Directory | [Uses]
BL 918 is a potent small-molecule activator of UNC-51-like kinase 1 (ULK1), a serine-threonine kinase involved in autophagy. Promotes cytoprotective autophagy in MPP+-treated SH-SY5Y cells, via the ULK complex. Improves motor dysfunction and reduces loss of dopaminergic neurons, mediated by MPTP, in in vivo models of Parkinson’s disease. |
| Chemical Properties | Back Directory | [density ]
1.508±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: ≥ 250 mg/mL (468.66 mM) | [form ]
A solid | [pka]
11.13±0.70(Predicted) | [color ]
White to off-white |
|
| Company Name: |
DC Chemicals
|
| Tel: |
021-58447131 13564518121 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList927327/0.htm |
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
|