| Identification | Back Directory | [Name]
(+)-Biotin-PEG8-NHS Ester | [CAS]
2143968-03-8 | [Synonyms]
Biotin-PEG8-SPA
(+)-Biotin-PEG8-NHS Ester | [Molecular Formula]
C33H56N4O14S | [MDL Number]
MFCD27977502 | [MOL File]
2143968-03-8.mol | [Molecular Weight]
764.88 |
| Hazard Information | Back Directory | [Biological Activity]
Biotin-PEG8-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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