| Identification | More | [Name]
2,4-DIFLUOROPYRIMIDINE | [CAS]
2802-61-1 | [Synonyms]
2,4-DIFLUOROPYRIMIDINE
Pyrimidine, 2,4-difluoro-(6CI,8CI,9CI)
2,4-Difluoropyrimidine 98%
2,4-Difluoropyrimidine98% | [EINECS(EC#)]
631-074-8 | [Molecular Formula]
C4H2F2N2 | [MDL Number]
MFCD04972830 | [Molecular Weight]
116.07 | [MOL File]
2802-61-1.mol |
| Questions And Answer | Back Directory | [Synthesis]
Crown ethers are able to enhance the performance of KF in two ways. Firstly,
they complex the potassium cation making a better fluoride source and secondly they
increase the solubility of KF in the solvent.
KF with a catalytic amount of dicyclohexano-18-crown-6 in tetraglyme converted
2,4-dichloropyrimidine into 2,4-difluoropyrimidine.
 |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R10:Flammable.
R22:Harmful if swallowed.
R37/38:Irritating to respiratory system and skin .
R41:Risk of serious damage to eyes. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S39:Wear eye/face protection . | [RIDADR ]
UN 1993 3/PG 3
| [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HazardClass ]
3 | [PackingGroup ]
III | [HS Code ]
29335990 |
| Hazard Information | Back Directory | [Uses]
2,4-Difluoropyrimidine can be used as a starting material to synthesize:
- 3-Pyrimidin-4-yl-oxazolidin-2-one derivatives as mutant isocitrate dehydrogenase (IDH1) inhibitors.
- N,N′-(1,4-phenylenebis(methylene))bis(2-fluoropyrimidin-4-amine) as chemokine receptor type 4 antagonists.
| [Synthesis Reference(s)]
Journal of Heterocyclic Chemistry, 22, p. 149, 1985 DOI: 10.1002/jhet.5570220137 |
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