| Identification | Back Directory | [Name]
(5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDE | [CAS]
354811-10-2 | [Synonyms]
IKK-2 INHIBITOR VI
IKK2 Inhibitor VI,IKK-2 Inhibitor VI
(5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDE
5-Phenyl-2-ureidothiophene-3-carboxylic Acid Amide
2-(carbamoylamino)-5-phenylthiophene-3-carboxamide
2-[(AMinocarbonyl)aMino]-5-phenyl-3-thiophenecarboxaMide
3-Thiophenecarboxamide, 2-[(aminocarbonyl)amino]-5-phenyl- | [Molecular Formula]
C12H11N3O2S | [MDL Number]
MFCD09037542 | [MOL File]
354811-10-2.mol | [Molecular Weight]
261.3 |
| Chemical Properties | Back Directory | [Melting point ]
>210°C (dec.) | [storage temp. ]
Refrigerator | [solubility ]
DMSO, Methanol (Slightly) | [form ]
Solid | [color ]
Light Beige to Light Brown |
| Hazard Information | Back Directory | [Description]
Inhibitor of NF-κB kinase 2 (IKK2, also known as IKKβ) acts as part of an IKK complex in the canonical NF-κB pathway, phosphorylating inhibitors of NF-κB (IκBs) to initiate signaling. NF-κB signaling can also occur through a non-canonical, IKK/IκB-independent pathway. IKK2 Inhibitor VI is a potent, cell-permeable, reversible inhibitor of IKK2 (IC50 = 13 nM). It is used to evaluate the role of the canonical, IκB-dependent NF-κB signaling pathway in cellular responses. | [Uses]
(5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDE is an inhibitor of NF-κB kinase 2 (IKK2, also known as IKKβ) acts as part of an IKK complex in the canonical NF-κB pathway, phosphorylating inhibitors of NF-κB (IκBs) to initiate signaling. NF-κB signaling can also occur through a non-canonical, IKK/IκB-independent pathway. IKK2 Inhibitor VI is a potent, cell-permeable, reversible inhibitor of IKK2 (IC50 = 13 nM). It is used to evaluate the role of the canonical, IκB-dependent NF-κB signaling pathway in cellular responses.
| [Uses]
An ureido-thiophenecarboxamide compound that acts as a potent inhibitor of IKK-2 (InhibitorVI) | [Uses]
An ureido-thiophenecarboxamide compound that acts as a potent inhibitor of IKK-2 (InhibitorVI). | [storage]
Store at -20°C |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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