| | 354811-10-2 Basic information More.. |
| Product Name: | (5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDE | | Synonyms: | (5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDE;IKK-2 INHIBITOR VI;2-[(AMinocarbonyl)aMino]-5-phenyl-3-thiophenecarboxaMide;2-(carbamoylamino)-5-phenylthiophene-3-carboxamide;3-Thiophenecarboxamide, 2-[(aminocarbonyl)amino]-5-phenyl-;5-Phenyl-2-ureidothiophene-3-carboxylic Acid Amide;IKK2 Inhibitor VI,IKK-2 Inhibitor VI;5-Phenyl-2-ureidothiophene-3-carboxylic Acid Amide|||IKK2 Inhibitor IV | | CAS: | 354811-10-2 | | MF: | C12H11N3O2S | | MW: | 261.3 | | EINECS: | | | Mol File: | Mol File |  |
Use
(5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDE is an inhibitor of NF-κB kinase 2 (IKK2, also known as IKKβ) acts as part of an IKK complex in the canonical NF-κB pathway, phosphorylating inhibitors of NF-κB (IκBs) to initiate signaling. NF-κB signaling can also occur through a non-canonical, IKK/IκB-independent pathway. IKK2 Inhibitor VI is a potent, cell-permeable, reversible inhibitor of IKK2 (IC50 = 13 nM). It is used to evaluate the role of the canonical, IκB-dependent NF-κB signaling pathway in cellular responses.
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354811-10-2
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