| Identification | More | [Name]
(S)-2-Benzylsuccinic acid | [CAS]
3972-36-9 | [Synonyms]
(S)-2-BENZYL-1,4-BUTANEDIOIC ACID
(S)-2-BENZYLSUCCINIC ACID
Mitiglinide intermediate 2
Mitiglinide intermediate 8
(S)-2-Benzylsuccinic acid (Mitiglinide) | [EINECS(EC#)]
609-742-5 | [Molecular Formula]
C11H12O4 | [MDL Number]
MFCD00798341 | [Molecular Weight]
208.21 | [MOL File]
3972-36-9.mol |
| Chemical Properties | Back Directory | [Melting point ]
164.0 to 168.0 °C | [Boiling point ]
331.4±22.0 °C(Predicted) | [density ]
1.290±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [form ]
powder to crystal | [pka]
3.97±0.10(Predicted) | [color ]
White to Almost white | [InChI]
InChI=1S/C11H12O4/c12-10(13)7-9(11(14)15)6-8-4-2-1-3-5-8/h1-5,9H,6-7H2,(H,12,13)(H,14,15)/t9-/m0/s1 | [InChIKey]
GTOFKXZQQDSVFH-VIFPVBQESA-N | [SMILES]
C(O)(=O)[C@@H](CC1=CC=CC=C1)CC(O)=O | [CAS DataBase Reference]
3972-36-9(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Description]
(S)-2-Benzylsuccinic acid is a widely used compound, which was employed as a key intermediate for hypoglycemic KAD-1229 by means of asymmetric alkylation of N-acylsulta. It can be synthesized by various procedures. The preparation of (S)-2-benzylsuccinic acid from L-phenylalanine is considered to be one of the most clean, efficient and convenient processes. The compound is a common chiral synthesis intermediate. | [Uses]
(S)-2-Benzylsuccinic acid is a common asymmetric synthesis intermediate in which the carboxyl group in the structure can be converted to common active functional groups, such as hydroxyl groups under the reduction of boranes. In addition, the two carboxyl groups in the structure can be heated and dehydrated and condensed in the presence of acetic anhydride or acetyl chloride to obtain the corresponding anhydride structure. |
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